Immunogenicity 5572

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
KCNH5
Transcript ID
NM_139318
HLA INFO
DRB*15:02
TCR INFO

No TCR info found!

T cell Tumor cell DRB*15:02
sequence
Full length protein sequence (988 aa)
MPGGK
1
RGLVA
6
PQNTF
11
LENIV
16
RRSSE
21
SSFLL
26
GNAQI
31
VDWPV
36
VYSND
41
GFCKL
46
SGYHR
51
ADVMQ
56
KSSTC
61
SFMYG
66
ELTDK
71
KTIEK
76
VRQTF
81
DNYES
86
NCFEV
91
LLYKK
96
NRTPV
101
WFYMQ
106
IAPIR
111
NEHEK
116
VVLFL
121
CTFKD
126
ITLFK
131
QPIED
136
DSTKG
141
WTKFA
146
RLTRA
151
LTNSR
156
SVLQQ
161
LTPMN
166
KTEVV
171
HKHSR
176
LAEVL
181
QLGSD
186
ILPQY
191
KQEAP
196
KTPPH
201
IILHY
206
CAFKT
211
TWDWV
216
ILILT
221
FYTAI
226
MVPYN
231
VSFKT
236
KQNNI
241
AWLVL
246
DSVVD
251
VIFLV
256
DIVLN
261
FHTTF
266
VGPGG
271
EVISD
276
PKLIR
281
MNYLK
286
TWFVI
291
DLLSC
296
LPYDI
301
INAFE
306
NVDEG
311
ISSLF
316
SSLKV
321
VRLLR
326
LGRVA
331
RKLDH
336
YLEYG
341
AAVLV
346
LLVCV
351
FGLVA
356
HWLAC
361
IWYSI
366
GDYEV
371
IDEVT
376
NTIQI
381
DSWLY
386
QLALS
391
IGTPY
396
RYNTS
401
AGIWE
406
GGPSK
411
DSLYV
416
SSLYF
421
TMTSL
426
TTIGF
431
GNIAP
436
TTDVE
441
KMFSV
446
AMMMV
451
GSLLY
456
ATIFG
461
NVTTI
466
FQQMY
471
ANTNR
476
YHEML
481
NNVRD
486
FLKLY
491
QVPKG
496
LSERV
501
MDYIV
506
STWSM
511
SKGID
516
TEKVL
521
SICPK
526
DMRAD
531
ICVHL
536
NRKVF
541
NEHPA
546
FRLAS
551
DGCLR
556
ALAVE
561
FQTIH
566
CAPGD
571
LIYHA
576
GESVD
581
ALCFV
586
VSGSL
591
EVIQD
596
DEVVA
601
ILGKG
606
DVFGD
611
IFWKE
616
TTLAH
621
ACANV
626
RALTY
631
CDLHI
636
IKREA
641
LLKVL
646
DFYTA
651
FANSF
656
SRNLT
661
LTCNL
666
RKRII
671
FRKIS
676
DVKKE
681
EEERL
686
RQKNE
691
VTLSI
696
PVDHP
701
VRKLF
706
QKFKQ
711
QKELR
716
NQGST
721
QGDPE
726
RNQLQ
731
VESRS
736
LQNGA
741
SITGT
746
SVVTV
751
SQITP
756
IQTSL
761
AYVKT
766
SESLK
771
QNNRD
776
AMELK
781
PNGGA
786
DQKCL
791
KVNSP
796
IRMKN
801
GNGKG
806
WLRLK
811
NNMGA
816
HEEKK
821
EDWNN
826
VTKAE
831
SMGLL
836
SEDPK
841
SSDSE
846
NSVTK
851
NPLRK
856
TDSCD
861
SGITK
866
SDLRL
871
DKAGE
876
ARSPL
881
EHSPI
886
QADAK
891
HPFYP
896
IPEQA
901
LQTTL
906
QEVKH
911
ELKED
916
IQLLS
921
CRMTA
926
LEKQV
931
AEILK
936
ILSEK
941
SVPQA
946
SSPKS
951
QMPLQ
956
VPPQI
961
PCQDI
966
FSVSR
971
PESPE
976
SDKDE
981
IHF
986
Mutation Information
DNA mutation:
None
Peptide Range:
154 ~ 178
Mut AA position:
166 (13 in Wild Type peptide)
Alignment
Wild Type:
"RALTNSRSVLQQLTPMNKTEVVHKH
||||||||||||.||||||||||||
Mutant:
RALTNSRSVLQQRTPMNKTEVVHKH"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) KCNH5

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay