Immunogenicity 5648

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
SIX4
Transcript ID
NM_017420
HLA INFO
B*40:01
TCR INFO

No TCR info found!

T cell Tumor cell B*40:01
sequence
Full length protein sequence (781 aa)
MSSSS
1
PTGQI
6
ASAAD
11
IKQEN
16
GMESA
21
SEGQE
26
AHREV
31
AGGAA
36
VGLSP
41
PAPAP
46
FPLEP
51
GDAAT
56
AAARV
61
SGEEG
66
AVAAA
71
AAGAA
76
ADQVQ
81
LHSEL
86
LGRHH
91
HAAAA
96
AAQTP
101
LAFSP
106
DHVAC
111
VCEAL
116
QQGGN
121
LDRLA
126
RFLWS
131
LPQSD
136
LLRGN
141
ESLLK
146
ARALV
151
AFHQG
156
IYPEL
161
YSILE
166
SHSFE
171
SANHP
176
LLQQL
181
WYKAR
186
YTEAE
191
RARGR
196
PLGAV
201
DKYRL
206
RRKFP
211
LPRTI
216
WDGEE
221
TVYCF
226
KEKSR
231
NALKE
236
LYKQN
241
RYPSP
246
AEKRH
251
LAKIT
256
GLSLT
261
QVSNW
266
FKNRR
271
QRDRN
276
PSETQ
281
SKSES
286
DGNPS
291
TEDES
296
SKGHE
301
DLSPH
306
PLSSS
311
SDGIT
316
NLSLS
321
SHMEP
326
VYMQQ
331
IGNAK
336
ISLSS
341
SGVLL
346
NGSLV
351
PASTS
356
PVFLN
361
GNSFI
366
QGPSG
371
VILNG
376
LNVGN
381
TQAVA
386
LNPPK
391
MSSNI
396
VSNGI
401
SMTDI
406
LGSTS
411
QDVKE
416
FKVLQ
421
SSANS
426
ATTTS
431
YSPSV
436
PVSFP
441
GLIPS
446
TEVKR
451
EGIQT
456
VASQD
461
GGSVV
466
TFTTP
471
VQINQ
476
YGIVQ
481
IPNSG
486
ANSQF
491
LNGSI
496
GFSPL
501
QLPPV
506
SVAAS
511
QGNIS
516
VSSST
521
SDGST
526
FTSES
531
TTVQQ
536
GKVFL
541
SSLAP
546
SAVVY
551
TVPNT
556
GQTIG
561
SVKQE
566
GLERS
571
LVFSQ
576
LMPVN
581
QNAQV
586
NANLS
591
SENIS
596
GSGLH
601
PLASS
606
LVNVS
611
PTHNF
616
SLSPS
621
TLLNP
626
TELNR
631
DIADS
636
QPMSA
641
PVASK
646
STVTS
651
VSNTN
656
YATLQ
661
NCSLI
666
TGQDL
671
LSVPM
676
TQAAL
681
GEIVP
686
TAEDQ
691
VGHPS
696
PAVHQ
701
DFVQE
706
HRLVL
711
QSVAN
716
MKENF
721
LSNSE
726
SKATS
731
SLMML
736
DSKSK
741
YVLDG
746
MVDTV
751
CEDLE
756
TDKKE
761
LAKLQ
766
TVQLD
771
EDMQD
776
L
781
Mutation Information
DNA mutation:
None
Peptide Range:
258 ~ 282
Mut AA position:
270 (13 in Wild Type peptide)
Alignment
Wild Type:
"KITGLSLTQVSNWFKNRRQRDRNPS
||||||||||||.||||||||||||
Mutant:
KITGLSLTQVSNCFKNRRQRDRNPS"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) SIX4

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay