Immunogenicity 5716

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
LUZP1
Transcript ID
NM_033631
HLA INFO
DQA*01:02 / DQB*06:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:02 DQB*06:02
sequence
Full length protein sequence (1076 aa)
MAEFT
1
SYKET
6
ASSRH
11
LRFKL
16
QSLSR
21
RLDEL
26
EEATK
31
NLQKA
36
EDELL
41
DLQDK
46
VIQAE
51
GSNSS
56
MLAEI
61
EVLRQ
66
RVLRI
71
EGKDE
76
EIKRA
81
EDLCR
86
LMKEK
91
LEEEE
96
NLTRE
101
LKSEI
106
ERLQK
111
RMAEL
116
EKLEE
121
AFSRS
126
KNDCT
131
QLCLS
136
LNEER
141
NLTKK
146
ISSEL
151
EMLRV
156
KVKEL
161
ESSED
166
RLDKT
171
EQSLA
176
SELEK
181
LKSLT
186
LSFVS
191
ERKYL
196
NEKEK
201
ENEKL
206
IKELT
211
QKLEQ
216
NKKMN
221
RDYTR
226
NASNL
231
ERNDL
236
RIEDG
241
ISSTL
246
PSKES
251
RRKGG
256
LDYLK
261
QVENE
266
TRNKS
271
ENEKN
276
RNQED
281
NKVKD
286
LNQEI
291
EKLKT
296
QIKHF
301
ESLEE
306
ELKKM
311
KSKNN
316
DLQDN
321
YLSEQ
326
NKNKL
331
LASQL
336
EEIKL
341
QIKKQ
346
KELEN
351
GEVEG
356
EDAFL
361
SSKGR
366
HERTK
371
FRGHG
376
SEASV
381
SKHTA
386
RELSP
391
QHKRE
396
RLRNR
401
EFALN
406
NENYS
411
LSNRQ
416
VSSPS
421
FTNRR
426
AAKAS
431
HMGVS
436
TDSGT
441
QETKK
446
TEDRF
451
VPGSS
456
QSEGK
461
KSREQ
466
PSVLS
471
RYPPA
476
AQEHS
481
KAWKG
486
TSKPG
491
TESGL
496
KGKVE
501
KTTRT
506
FSDTT
511
HGSVP
516
SDPLG
521
RADKA
526
SDTSS
531
ETVFG
536
KRGHV
541
LGNGS
546
QVTQA
551
ANSGC
556
SKAIG
561
ALASS
566
RRSSS
571
EGLSK
576
GKKAA
581
NGLEA
586
DNSCP
591
NSKAP
596
VLSKY
601
PYSCR
606
SQENI
611
LQGFS
616
TSHKE
621
GVNQP
626
AAVVM
631
EDSSP
636
HEALR
641
CRVIK
646
SSGRE
651
KPDSD
656
DDLDI
661
ASLVT
666
AKLVN
671
TTITP
676
EPEPK
681
PQPNS
686
REKAK
691
TRGAP
696
RTSLF
701
ENDKD
706
AGMEN
711
ESVKS
716
VRAST
721
NTMEL
726
PDTNG
731
AGVKS
736
QRPFS
741
PREAL
746
RSRAI
751
IKPVI
756
VDKDV
761
KKIMG
766
GSGTE
771
TTLEK
776
QKPVS
781
KPGPN
786
KVTSS
791
ITIYP
796
SDSSS
801
PRAAP
806
GEALR
811
ERHTS
816
TSNIQ
821
VGLAE
826
LTSVS
831
NHVSS
836
PFELS
841
IHKHD
846
ITLQL
851
AEAER
856
MADGP
861
LKDRP
866
ETVVS
871
RSSII
876
IKPSD
881
PVERN
886
SHAPP
891
AETIR
896
WKSHS
901
APSEV
906
GFSDA
911
RHVTV
916
RNAWK
921
SRRDL
926
KSLED
931
PPTRI
936
GKNVE
941
STNSN
946
AYTQR
951
SSTDF
956
SELEQ
961
PRSCL
966
FEQGT
971
RRVGP
976
SSGDA
981
PEPSS
986
RRTQS
991
SLTVS
996
EVLTR
1001
RNRVG
1006
DTITV
1011
AAWNH
1016
SASME
1021
EEGED
1026
CTLSV
1031
YRQLH
1036
NSLDP
1041
SELPG
1046
KQGLP
1051
ESGRV
1056
RAEER
1061
LRPTR
1066
PCAEE
1071
N
1076
Mutation Information
DNA mutation:
None
Peptide Range:
72 ~ 96
Mut AA position:
84 (13 in Wild Type peptide)
Alignment
Wild Type:
"VLRIEGKDEEIKRAEDLCRLMKEKL
||||||||||||.||||||||||||
Mutant:
VLRIEGKDEEIKTAEDLCRLMKEKL"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) LUZP1

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay