Immunogenicity 5746

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
PARL
Transcript ID
NM_001037639
HLA INFO
DQA*01:03 / DQB*06:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:03 DQB*06:02
sequence
Full length protein sequence (329 aa)
MAWRG
1
WAQRG
6
WGCGQ
11
AWGAS
16
VGGRS
21
CEELT
26
AVLTP
31
PQLLG
36
RRFNF
41
FIQQK
46
CGFRK
51
APRKV
56
EPRRS
61
DPGTS
66
GEAYK
71
RSALI
76
PPVEE
81
TVFYP
86
SPYPI
91
RSLIK
96
PLFFT
101
VGFTG
106
CAFGS
111
AAIWQ
116
YESLK
121
SRVQS
126
YFDGI
131
KADWL
136
DSIRP
141
QKEGD
146
FRKEI
151
NKWWN
156
NLSDG
161
QRTVT
166
GIIAA
171
NVLVF
176
CLWRV
181
PSLQR
186
TMIRY
191
FTSNP
196
ASSVI
201
SNFVS
206
YVGKV
211
ATGRY
216
GPSLG
221
ASGAI
226
MTVLA
231
AVCTK
236
IPEGR
241
LAIIF
246
LPMFT
251
FTAGN
256
ALKAI
261
IAMDT
266
AGMIL
271
GWKFF
276
DHAAH
281
LGGAL
286
FGIWY
291
VTYGH
296
ELIWK
301
NREPL
306
VKIWH
311
EIRTN
316
GPKKG
321
GGSK
326
Mutation Information
DNA mutation:
None
Peptide Range:
22 ~ 46
Mut AA position:
34 (13 in Wild Type peptide)
Alignment
Wild Type:
"GGRSCEELTAVLTPPQLLGRRFNFF
||||||||||||.||||||||||||
Mutant:
GGRSCEELTAVLPPPQLLGRRFNFF"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) PARL

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay