Immunogenicity 6035

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
DENND2C
Transcript ID
NM_001256404
HLA INFO
B*07:02
TCR INFO

No TCR info found!

T cell Tumor cell B*07:02
sequence
Full length protein sequence (928 aa)
MDVGF
1
SRTTV
6
QTLSR
11
SHCKN
16
IKQKI
21
SQWEG
26
RANGI
31
SNPEK
36
WCPKD
41
FGVRY
46
NCHQE
51
IRLKK
56
NPIAE
61
RKSKN
66
LDVTS
71
RENVG
76
LDINE
81
NTKSH
86
DQSEN
91
ENKKH
96
EYDDT
101
HFFKN
106
ESESN
111
WVCSR
116
VKEIE
121
SCKED
126
VLDPE
131
TSLPP
136
GNFYT
141
SQILW
146
KKIEA
151
LPPDK
156
LLNLA
161
LEHCD
166
SSEKE
171
LNFRV
176
LDSSY
181
GITKS
186
LENIY
191
SEPEG
196
QECGP
201
SINPL
206
PKPRR
211
TFRYL
216
SESGV
221
TPYKE
226
RNCDK
231
KYCEN
236
NSCAQ
241
SSLAS
246
SQEPE
251
PKKYG
256
GKIRG
261
RSKRK
266
SFEFE
271
DIQHF
276
RNRNS
281
QTIRE
286
ELGRN
291
SGSAL
296
YYTQS
301
EDNIY
306
EDIIY
311
PTKEN
316
PYEDI
321
PVQPL
326
PMWRS
331
PSAWK
336
LPPAK
341
SAFKA
346
PKLPP
351
KPQFL
356
HRKTM
361
EVKNS
366
QAYLR
371
SKLTK
376
DTTLP
381
VTLTE
386
WKLFR
391
AGEVA
396
NTKRK
401
NLPRL
406
VLKID
411
DIFES
416
KRGKK
421
KVKLH
426
SYTGK
431
ELPPT
436
KGETS
441
GNESD
446
AEYLP
451
KNRHK
456
RLAQL
461
QPSSK
466
RNPHY
471
QTLER
476
DLIEL
481
QEQQL
486
FELFV
491
VVSLQ
496
KKPSG
501
ISYIP
506
QVIQQ
511
FPGKD
516
DHGYK
521
QSKDM
526
EERLK
531
VIPKF
536
CFPDS
541
KDWMP
546
TSELK
551
SETFS
556
FVLTG
561
EDGSR
566
WFGYC
571
KKLLP
576
VGKGK
581
RLPEV
586
YCMVS
591
RLGCF
596
NLFSK
601
ILDEV
606
EKRRE
611
MSPAL
616
VYPFM
621
RSVME
626
APFPA
631
PGRTI
636
TVKSY
641
LPGAG
646
DESIE
651
LCRPL
656
DSRLE
661
HVDFK
666
CLFKC
671
LSVCH
676
LIRVC
681
ASLLL
686
ERRVI
691
FVANS
696
LSTLS
701
KCGHA
706
VVATL
711
YPFTW
716
QHTYI
721
PVLPA
726
SMIDI
731
VCSPT
736
PFLIG
741
ILSCS
746
LPQLQ
751
DLPIE
756
EVLIV
761
DLCAD
766
KFLQE
771
VSDED
776
EILPP
781
KLQAA
786
LMQIL
791
EERNE
796
ILTQE
801
QNFSQ
806
DVTLN
811
SLVSE
816
AFVRF
821
FVELV
826
GHYSL
831
NMTVT
836
ERGER
841
VFQRE
846
PFRKS
851
HTSRS
856
VRHFL
861
DLFME
866
TQMFA
871
GFIQD
876
RELRK
881
SGVKG
886
LFEIR
891
AIQYL
896
ETIPE
901
SEPSG
906
MNRIL
911
RSLGS
916
KMKFL
921
QKK
926
Mutation Information
DNA mutation:
None
Peptide Range:
269 ~ 293
Mut AA position:
281 (13 in Wild Type peptide)
Alignment
Wild Type:
"RKSFEFEDIQHFRNRNSQTIREELG
||||||||||||.||||||||||||
Mutant:
RKSFEFEDIQHFQNRNSQTIREELG"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) DENND2C

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay