Immunogenicity 6204
Sample ID
3995
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
SHANK1
Transcript ID
NM_016148
HLA INFO
DRB*07:01
TCR INFO
No TCR info found!
Full length protein sequence (2161 aa)
MTHSP
1
ATSED
6
EERHS
11
ASECP
16
EGGSE
21
SDSSP
26
DGPGR
31
GPRGT
36
RGQGS
41
GAPGS
46
LASVR
51
GLQGR
56
SMSVP
61
DDAHF
66
SMMVF
71
RIGIP
76
DLHQT
81
KCLRF
86
NPDAT
91
IWTAK
96
QQVLC
101
ALSES
106
LQDVL
111
NYGLF
116
QPATS
121
GRDAN
126
FLEEE
131
RLLRE
136
YPQSF
141
EKGVP
146
YLEFR
151
YKTRV
156
YKQTN
161
LDEKQ
166
LAKLH
171
TKTGL
176
KKFLE
181
YVQLG
186
TSDKV
191
ARLLD
196
KGLDP
201
NYHDS
206
DSGET
211
PLTLA
216
AQTEG
221
SVEVI
226
RTLCL
231
GGAHI
236
DFRAR
241
DGMTA
246
LHKAA
251
CARHC
256
LALTA
261
LLDLG
266
GSPNY
271
KDRRG
276
LTPLF
281
HTAMV
286
GGDPR
291
CCELL
296
LFNRA
301
QLGIA
306
DENGW
311
QEIHQ
316
ACQRG
321
HSQHL
326
EHLLF
331
YGAEP
336
GAQNA
341
SGNTA
346
LHICA
351
LYNKE
356
TCARI
361
LLYRG
366
ADKDV
371
KNNNG
376
QTPFQ
381
VAVIA
386
GNFEL
391
GELIR
396
NHREQ
401
DVVPF
406
QESPK
411
YAARR
416
RGPPG
421
TGLTV
426
PPALL
431
RANSD
436
TSMAL
441
PDWMV
446
FSAPG
451
AASSG
456
APGPT
461
SGSQG
466
QSQPS
471
APTTK
476
LSSGT
481
LRSAS
486
SPRGA
491
RARSP
496
SRGRH
501
PEDAK
506
RQPRG
511
RPSSS
516
GTPRE
521
GPAGG
526
TGGSG
531
GPGGS
536
LGSRG
541
RRRKL
546
YSAVP
551
GRSFM
556
AVKSY
561
QAQAE
566
GEISL
571
SKGEK
576
IKVLS
581
IGEGG
586
FWEGQ
591
VKGRV
596
GWFPS
601
DCLEE
606
VANRS
611
QESKQ
616
ESRSD
621
KAKRL
626
FRHYT
631
VGSYD
636
SFDAP
641
SLMDG
646
IGPGS
651
DYIIK
656
EKTVL
661
LQKKD
666
SEGFG
671
FVLRG
676
AKAQT
681
PIEEF
686
TPTPA
691
FPALQ
696
YLESV
701
DEGGV
706
AWRAG
711
LRMGD
716
FLIEV
721
NGQNV
726
VKVGH
731
RQVVN
736
MIRQG
741
GNTLM
746
VKVVM
751
VTRHP
756
DMDEA
761
VHKKA
766
PQQAK
771
RLPPP
776
TISLR
781
SKSMT
786
SELEE
791
MEYEQ
796
QPAPV
801
PSMEK
806
KRTVY
811
QMALN
816
KLDEI
821
LAAAQ
826
QTISA
831
SESPG
836
PGGLA
841
SLGKH
846
RPKGF
851
FATES
856
SFDPH
861
HRAQP
866
SYERP
871
SFLPP
876
GPGLM
881
LRQKS
886
IGAAE
891
DDRPY
896
LAPPA
901
MKFSR
906
SLSVP
911
GSEDI
916
PPPPT
921
TSPPE
926
PPYST
931
PPVPS
936
SSGRL
941
TPSPR
946
GGPFN
951
PGSGG
956
PLPAS
961
SPASF
966
DGPSP
971
PDTRV
976
GSREK
981
SLYHS
986
GPLPP
991
AHHHP
996
PHHHH
1001
HHAPP
1006
PQPHH
1011
HHAHP
1016
PHPPE
1021
METGG
1026
SPDDP
1031
PPRLA
1036
LGPQP
1041
SLRGW
1046
RGGGP
1051
SPTPG
1056
APSPS
1061
HHGSA
1066
GGGGG
1071
SSQGP
1076
ALRYF
1081
QLPPR
1086
AASAA
1091
MYVPA
1096
RSGRG
1101
RKGPL
1106
VKQTK
1111
VEGEP
1116
QKGGG
1121
LPPAP
1126
SPTSP
1131
ASPQP
1136
PPAVA
1141
APSEK
1146
NSIPI
1151
PTIII
1156
KAPST
1161
SSSGR
1166
SSQGS
1171
STEAE
1176
PPTQP
1181
EPTGG
1186
GGGGG
1191
SSPSP
1196
APAMS
1201
PVPPS
1206
PSPVP
1211
TPASP
1216
SGPAT
1221
LDFTS
1226
QFGAA
1231
LVGAA
1236
RREGG
1241
WQNEA
1246
RRRST
1251
LFLST
1256
DAGDE
1261
DGGDG
1266
GLGTG
1271
AAPGP
1276
RLRHS
1281
KSIDE
1286
GMFSA
1291
EPYLR
1296
LESAG
1301
SGAGY
1306
GGYGA
1311
GSRAY
1316
GGGGG
1321
SSAFT
1326
SFLPP
1331
RPLVH
1336
PLTGK
1341
ALDPA
1346
SPLGL
1351
ALAAR
1356
ERALK
1361
ESSEG
1366
GGAPQ
1371
PPPRP
1376
PSPRY
1381
EAPPP
1386
TPHHH
1391
SPHAH
1396
HEPVL
1401
RLWGA
1406
SPPDP
1411
ARREL
1416
GYRAG
1421
LGSQE
1426
KSLPA
1431
SPPAA
1436
RRSLL
1441
HRLPP
1446
TAPGV
1451
GPLLL
1456
QLGTE
1461
PPAPH
1466
PGVSK
1471
PWRSA
1476
APEEP
1481
ERLPL
1486
HVRFL
1491
ENCQP
1496
RAPVT
1501
SGRGP
1506
PSEDG
1511
PGVPP
1516
PSPRR
1521
SVPPS
1526
PTSPR
1531
ASEEN
1536
GLPLL
1541
VLPPP
1546
APSVD
1551
VEDGE
1556
FLFVE
1561
PLPPP
1566
LEFSN
1571
SFEKP
1576
ESPLT
1581
PGPPH
1586
PLPDT
1591
PAPAT
1596
PLPPV
1601
PPPAV
1606
AAAPP
1611
TLDST
1616
ASSLT
1621
SYDSE
1626
VATLT
1631
QGASA
1636
APGDP
1641
HPPGP
1646
PAPAA
1651
PAPAA
1656
PQPGP
1661
DPPPG
1666
TDSGI
1671
EEVDS
1676
RSSSD
1681
HPLET
1686
ISSAS
1691
TLSSL
1696
SAEGG
1701
GSAGG
1706
GGGAG
1711
AGVAS
1716
GPELL
1721
DTYVA
1726
YLDGQ
1731
AFGGS
1736
STPGP
1741
PYPPQ
1746
LMTPS
1751
KLRGR
1756
ALGAS
1761
GGLRP
1766
GPSGG
1771
LRDPV
1776
TPTSP
1781
TVSVT
1786
GAGTD
1791
GLLAL
1796
RACSG
1801
PPTAG
1806
VAGGP
1811
VAVEP
1816
EVPPV
1821
PLPTA
1826
SSLPR
1831
KLLPW
1836
EEGPG
1841
PPPPP
1846
LPGPL
1851
AQPQA
1856
SALAT
1861
VKASI
1866
ISELS
1871
SKLQQ
1876
FGGSS
1881
AAGGA
1886
LPWAR
1891
GGSGG
1896
GGDSH
1901
HGGAS
1906
YVPER
1911
TSSLQ
1916
RQRLS
1921
DDSQS
1926
SLLSK
1931
PVSSL
1936
FQNWP
1941
KPPLP
1946
PLPTG
1951
TGVSP
1956
TAAAA
1961
PGATS
1966
PSASS
1971
SSTST
1976
RHLQG
1981
VEFEM
1986
RPPLL
1991
RRAPS
1996
PSLLP
2001
ASEHK
2006
VSPAP
2011
RPSSL
2016
PILPS
2021
GPLYP
2026
GLFDI
2031
RGSPT
2036
GGAGG
2041
SADPF
2046
APVFV
2051
PPHPG
2056
ISGGL
2061
GGALS
2066
GASRS
2071
LSPTR
2076
LLSLP
2081
PDKPF
2086
GAKPL
2091
GFWTK
2096
FDVAD
2101
WLEWL
2106
GLAEH
2111
RAQFL
2116
DHEID
2121
GSHLP
2126
ALTKE
2131
DYVDL
2136
GVTRV
2141
GHRMN
2146
IDRAL
2151
KFFLE
2156
R
2161
Mutation Information
DNA mutation:
None
Peptide Range:
212 ~ 236
Mut AA position:
224 (13 in Wild Type peptide)
Alignment
Wild Type:
"SGETPLTLAAQTEGSVEVIRTLCLG
||||||||||||.||||||||||||
Mutant:
SGETPLTLAAQTKGSVEVIRTLCLG"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) SHANK1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay