Immunogenicity 6219
Sample ID
3995
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
PLEKHG4
Transcript ID
NM_001129727
HLA INFO
C*08:02
TCR INFO
No TCR info found!
Full length protein sequence (1191 aa)
MERPL
1
ENGDE
6
SPDSQ
11
GHATD
16
WRFAV
21
CSFRD
26
AWEEE
31
EPASQ
36
MHVKD
41
PGPPR
46
PPAGA
51
TQDEE
56
LQGSP
61
LSRKF
66
QLPPA
71
ADESG
76
DAQRG
81
TVESS
86
SVLSE
91
GPGPS
96
GVESL
101
LCPMS
106
SHLSL
111
AQGES
116
DTPGV
121
GLVGD
126
PGPSR
131
AMPSG
136
LSPGA
141
LDSDP
146
VGLGD
151
PLSEI
156
SKLLE
161
AAPSG
166
SGLPK
171
PADCL
176
LAQDL
181
CWELL
186
ASGMA
191
TLPGT
196
RDVQG
201
RAVLL
206
LCAHS
211
PAWLQ
216
SECSS
221
QELIR
226
LLLYL
231
RSIPR
236
PEVQA
241
LGLTV
246
LVDAR
251
ICAPS
256
SSLFS
261
GLSQL
266
QEAAP
271
GAVYQ
276
VLLVG
281
STLLK
286
EVPSG
291
LQLEQ
296
LPSQS
301
LLTHI
306
PTAGL
311
PTSLG
316
GGLPY
321
CHQAW
326
LDFRR
331
RLEAL
336
LQNCQ
341
AACAL
346
LQGAI
351
ESVKA
356
VPQPM
361
EPGEV
366
GQLLQ
371
QTEVL
376
MQQVL
381
DSPWL
386
AWLQC
391
QGGRE
396
LTWLK
401
QEVPE
406
VTLSP
411
DYRTA
416
MDKAD
421
ELYDR
426
VDGLL
431
HQLTL
436
QSNQR
441
IQALE
446
LVQTL
451
EARES
456
GLHQI
461
EVWLQ
466
QVGWP
471
ALEEA
476
GEPSL
481
DMLLQ
486
AQGSF
491
QELYQ
496
VAQEQ
501
VRQGE
506
KFLQP
511
LTGWE
516
AAELD
521
PPGAR
526
FLALR
531
AQLTE
536
FSRAL
541
AQRCQ
546
RLADA
551
ERLFQ
556
LFREA
561
LTWAE
566
EGQRV
571
LAELE
576
QERPG
581
VVLQQ
586
LQLHW
591
TRHPD
596
LPPAH
601
FRKMW
606
ALATG
611
LGSEA
616
IRQEC
621
RWAWA
626
RCQDT
631
WLALD
636
QKLEA
641
SLKLP
646
PVGST
651
ASLCV
656
SQVPA
661
APAHP
666
PLRKA
671
YSFDR
676
NLGQS
681
LSEPA
686
CHCHH
691
AATIA
696
ACRRP
701
EAGGG
706
ALPQA
711
SPTVP
716
PPGSS
721
DPRSL
726
NRLQL
731
VLAEM
736
VATER
741
EYVRA
746
LEYTM
751
ENYFP
756
ELDRP
761
DVPQG
766
LRGQR
771
AHLFG
776
NLEKL
781
RDFHC
786
HFFLR
791
ELEAC
796
TRHPP
801
RVAYA
806
FLRHR
811
VQFGM
816
YALYS
821
KNKPR
826
SDALM
831
SSYGH
836
TFFKD
841
KQQAL
846
GDHLD
851
LASYL
856
LKPIQ
861
RMGKY
866
ALLLQ
871
ELARA
876
CGGPT
881
QELSA
886
LREAQ
891
SLVHF
896
QLRHG
901
NDLLA
906
MDAIQ
911
GCDVN
916
LKEQG
921
QLVRQ
926
DEFVV
931
RTGRH
936
KSVRR
941
IFLFE
946
ELLLF
951
SKPRH
956
GPTGV
961
DTFAY
966
KRSFK
971
MADLG
976
LTECC
981
GNSNL
986
RFEIW
991
FRRRK
996
ARDTF
1001
VLQAS
1006
SLAIK
1011
QAWTA
1016
DISHL
1021
LWRQA
1026
VHNKE
1031
VRMAE
1036
MVSMG
1041
VGNKA
1046
FRDIA
1051
PSEEA
1056
INDRT
1061
VNYVL
1066
KCREV
1071
RSRAS
1076
IAVAP
1081
FDHDS
1086
LYLGA
1091
SNSLP
1096
GDPAS
1101
CSVLG
1106
SLNLH
1111
LYRDP
1116
ALLGL
1121
RCPLY
1126
PSFPE
1131
EAALE
1136
AEAEL
1141
GGQPS
1146
LTAED
1151
SEISS
1156
QCPSA
1161
SGSSG
1166
SDSSC
1171
VSGQA
1176
LGRGL
1181
EDLPC
1186
V
1191
Mutation Information
DNA mutation:
None
Peptide Range:
614 ~ 638
Mut AA position:
626 (13 in Wild Type peptide)
Alignment
Wild Type:
"TGLGSEAIRQECRWAWARCQDTWLA
||||||||||||.||||||||||||
Mutant:
TGLGSEAIRQECPWAWARCQDTWLA"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) PLEKHG4
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay