Immunogenicity 6263

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
PCDH17
Transcript ID
NM_001040429
HLA INFO
C*07:02
TCR INFO

No TCR info found!

T cell Tumor cell C*07:02
sequence
Full length protein sequence (1159 aa)
MYLSI
1
CCCFL
6
LWAPA
11
LTLKN
16
LNYSV
21
PEEQG
26
AGTVI
31
GNIGR
36
DARLQ
41
PGLPP
46
AERGG
51
GGRSK
56
SGSYR
61
VLENS
66
APHLL
71
DVDAD
76
SGLLY
81
TKQRI
86
DRESL
91
CRHNA
96
KCQLS
101
LEVFA
106
NDKEI
111
CMIKV
116
EIQDI
121
NDNAP
126
SFSSD
131
QIEMD
136
ISENA
141
APGTR
146
FPLTS
151
AHDPD
156
AGENG
161
LRTYL
166
LTRDD
171
HGLFG
176
LDVKS
181
RGDGT
186
KFPEL
191
VIQKA
196
LDREQ
201
QNHHT
206
LVLTA
211
LDGGE
216
PPRSA
221
TVQIN
226
VKVID
231
SNDNS
236
PVFEA
241
PSYLV
246
ELPEN
251
APLGT
256
VVIDL
261
NATDA
266
DEGPN
271
GEVLY
276
SFSSY
281
VPDRV
286
RELFS
291
IDPKT
296
GLIRV
301
KGNLD
306
YEENG
311
MLEID
316
VQARD
321
LGPNP
326
IPAHC
331
KVTVK
336
LIDRN
341
DNAPS
346
IGFVS
351
VRQGA
356
LSEAA
361
PPGTV
366
IALVR
371
VTDRD
376
SGKNG
381
QLQCR
386
VLGGG
391
GTGGG
396
GGLGG
401
PGGSV
406
PFKLE
411
ENYDN
416
FYTVV
421
TDRPL
426
DRETQ
431
DEYNV
436
TIVAR
441
DGGSP
446
PLNST
451
KSFAI
456
KILDE
461
NDNPP
466
RFTKG
471
LYVLQ
476
VHENN
481
IPGEY
486
LGSVL
491
AQDPD
496
LGQNG
501
TVSYS
506
ILPSH
511
IGDVS
516
IYTYV
521
SVNPT
526
NGAIY
531
ALRSF
536
NFEQT
541
KAFEF
546
KVLAK
551
DSGAP
556
AHLES
561
NATVR
566
VTVLD
571
VNDNA
576
PVIVL
581
PTLQN
586
DTAEL
591
QVPRN
596
AGLGY
601
LVSTV
606
RALDS
611
DFGES
616
GRLTY
621
EIVDG
626
NDDHL
631
FEIDP
636
SSGEI
641
RTLHP
646
FWEDV
651
TPVVE
656
LVVKV
661
TDHGK
666
PTLSA
671
VAKLI
676
IRSVS
681
GSLPE
686
GVPRV
691
NGEQH
696
HWDMS
701
LPLIV
706
TLSTI
711
SIILL
716
AAMIT
721
IAVKC
726
KRENK
731
EIRTY
736
NCRIA
741
EYSHP
746
QLGGG
751
KGKKK
756
KINKN
761
DIMLV
766
QSEVE
771
ERNAM
776
NVMNV
781
VSSPS
786
LATSP
791
MYFDY
796
QTRLP
801
LSSPR
806
SEVMY
811
LKPAS
816
NNLTV
821
PQGHA
826
GCHTS
831
FTGQG
836
TNASE
841
TPATR
846
MSIIQ
851
TDNFP
856
AEPNY
861
MGSRQ
866
QFVQS
871
SSTFK
876
DPERA
881
SLRDS
886
GHGDS
891
DQADS
896
DQDTN
901
KGSCC
906
DMSVR
911
EALKM
916
KTTST
921
KSQPL
926
EQEPE
931
ECVNC
936
TDECR
941
VLGHS
946
DRCWM
951
PQFPA
956
ANQAE
961
NADYR
966
TNLFV
971
PTVEA
976
NVETE
981
TYETV
986
NPTGK
991
KTFCT
996
FGKDK
1001
REHTI
1006
LIANV
1011
KPYLK
1016
AKRAL
1021
SPLLQ
1026
EVPSA
1031
SSSPT
1036
KACIE
1041
PCTST
1046
KGSLD
1051
GCEAK
1056
PGALA
1061
EASSQ
1066
YLPTD
1071
SQYLS
1076
PSKQP
1081
RDPPF
1086
MASDQ
1091
MARVF
1096
ADVHS
1101
RASRD
1106
SSEMG
1111
AVLEQ
1116
LDHPN
1121
RDLGR
1126
ESVDA
1131
EEVVR
1136
EIDKL
1141
LQDCR
1146
GNDPV
1151
AVRK
1156
Mutation Information
DNA mutation:
None
Peptide Range:
524 ~ 548
Mut AA position:
536 (13 in Wild Type peptide)
Alignment
Wild Type:
"YVSVNPTNGAIYALRSFNFEQTKAF
||||||||||||.||||||||||||
Mutant:
YVSVNPTNGAIYTLRSFNFEQTKAF"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) PCDH17

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay