Immunogenicity 6478

summary
Sample ID
3978
Response
Negative
Tumor Type
Bile duct cancer
Gene Symbol
RASGRP4
Transcript ID
NM_001146207
HLA INFO
DQA*05:01 / DQB*04:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*05:01 DQB*04:02
sequence
Full length protein sequence (576 aa)
MNRKD
1
SKRKS
6
HQECT
11
GKIGG
16
RGRPR
21
QVRRH
26
KTCPS
31
PREIS
36
KVMAS
41
MNLGL
46
LSEGG
51
CSEDE
56
LLEKC
61
IQSFD
66
SAGSL
71
CHEDH
76
MLNMV
81
LAMHS
86
WVLPS
91
ADLAA
96
RLLTS
101
YQKAT
106
GDTQE
111
LRRLQ
116
ICHLV
121
RYWLM
126
RHPEV
131
MHQDP
136
QLEEV
141
IGRFW
146
ATVAR
151
EGNSA
156
QRRLG
161
DSSDL
166
LSPGG
171
PGPPL
176
PMSSP
181
GLGKK
186
RKVSL
191
LFDHL
196
ETGEL
201
AQHLT
206
YLEFR
211
SFQAI
216
TALLE
221
LTELL
226
ASHNN
231
YARYR
236
RTWAG
241
CAGFR
246
LPVLG
251
VHLKD
256
LVSLH
261
EAQPD
266
RLPDG
271
RLHLP
276
KLNNL
281
YLRLQ
286
ELVAL
291
QGQHP
296
PCSAN
301
EDLLH
306
LLTLS
311
LDLFY
316
TEDEI
321
YELSY
326
AREPR
331
CPKSL
336
PPSPF
341
NAPLV
346
VEWAP
351
GVTPK
356
PDRVT
361
LGRHV
366
EQLVE
371
SVFKN
376
YDPEG
381
RGTIS
386
QEDFE
391
RLSGN
396
FPFAC
401
HGLHP
406
PPRQG
411
RGSFS
416
REELT
421
GYLLR
426
ASAIC
431
SKLGL
436
AFLHT
441
FHEVT
446
FRKPT
451
FCDSC
456
SGFLW
461
GVTKQ
466
GYRCR
471
ECGLC
476
CHKHC
481
RDQVK
486
VECKK
491
RPGAK
496
GDAGP
501
PGAPV
506
PSTPA
511
PHASC
516
GSEEN
521
HSYTL
526
SLEPE
531
TGCQL
536
RHAWT
541
QTESP
546
HPSWE
551
TDTVP
556
CPVMD
561
PPSTA
566
SSKLD
571
S
576
Mutation Information
DNA mutation:
None
Peptide Range:
304 ~ 328
Mut AA position:
316 (13 in Wild Type peptide)
Alignment
Wild Type:
"ANEDLLHLLTLSLDLFYTEDEIYEL
||||||||||||.||||||||||||
Mutant:
ANEDLLHLLTLSMDLFYTEDEIYEL"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) RASGRP4

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay