Immunogenicity 6493

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
TNRC6B
Transcript ID
NM_001024843
HLA INFO
C*12:03
TCR INFO

No TCR info found!

T cell Tumor cell C*12:03
sequence
Full length protein sequence (1029 aa)
MQTNE
1
GEVSE
6
ESSSK
11
VEQED
16
FVMEG
21
HGKTP
26
PPGEE
31
SKQEK
36
EQERE
41
EQLME
46
DKKRK
51
KEDKK
56
KKEAT
61
QKVTE
66
QKTKV
71
PEVTK
76
PSLSQ
81
PTAAS
86
PIGSS
91
PSPPV
96
NGGNN
101
AKRVA
106
VPNGQ
111
PPSAA
116
RYMPR
121
EVPPR
126
FRCQQ
131
DHKVL
136
LKRGQ
141
PPPPS
146
CMLLG
151
GGAGP
156
PPCTA
161
PGANP
166
NNAQV
171
TGALL
176
QSESG
181
TAPVW
186
SKSTP
191
PAPDN
196
GTSAW
201
GEPNE
206
SSPGW
211
GEMDD
216
TGAST
221
TGWGN
226
TPANA
231
PNAMK
236
PNSKS
241
MQDGW
246
GESDG
251
PVTGA
256
RHPSW
261
EEEED
266
GGVWN
271
TTGSQ
276
GSASS
281
HNSAS
286
WGQGG
291
KKQMK
296
CSLKG
301
GNNDS
306
WMNPL
311
AKQFS
316
NMGLL
321
SQTED
326
NPSSK
331
MDLSV
336
GSLSD
341
KKFDV
346
DKRAM
351
NLGDF
356
NDIMR
361
KDRSG
366
FRPPN
371
SKDMG
376
TTDSG
381
PYFEK
386
GGSHG
391
LFGNS
396
TAQSR
401
GLHTP
406
VQPLN
411
SSPSL
416
RAQVP
421
PQFIS
426
PQVSA
431
SMLKQ
436
FPNSG
441
LSPGL
446
FNVGP
451
QLSPQ
456
QIAML
461
SQLPQ
466
IPQFQ
471
LACQL
476
LLQQQ
481
QQQQL
486
LQNQR
491
KISQA
496
VRQQQ
501
EQQLA
506
RMVSA
511
LQQQQ
516
QQQQR
521
QPGMK
526
HSPSH
531
PVGPK
536
PHLDN
541
MVPNA
546
LNVGL
551
PDLQT
556
KGPIP
561
GYGSG
566
FSSGG
571
MDYGM
576
VGGKE
581
AGTES
586
RFKQW
591
TSMME
596
GLPSV
601
ATQEA
606
NMHKN
611
GAIVA
616
PGKTR
621
GGSPY
626
NQFDI
631
IPGDT
636
LGGHT
641
GPAGD
646
SWLPA
651
KSPPT
656
NKIGS
661
KSSNA
666
SWPPE
671
FQPGV
676
PWKGI
681
QNIDP
686
ESDPY
691
VTPGS
696
VLGGT
701
ATSPI
706
VDTDH
711
QLLRD
716
NTTGS
721
NSSLN
726
TSLPS
731
PGAWP
736
YSASD
741
NSFTN
746
VHSTS
751
AKFPD
756
YKSTW
761
SPDPI
766
GHNPT
771
HLSNK
776
MWKNH
781
ISSRN
786
TTPLP
791
RPPPG
796
LTNPK
801
PSSPW
806
SSTAP
811
RSVRG
816
WGTQD
821
SRLAS
826
ASTWS
831
DGGSV
836
RPSYW
841
LVLHN
846
LTPQI
851
DGSTL
856
RTICM
861
QHGPL
866
LTFHL
871
NLTQG
876
TALIR
881
YSTKQ
886
EAAKA
891
QTALH
896
MCVLG
901
NTTIL
906
AEFAT
911
DDEVS
916
RFLAQ
921
AQPPT
926
PAATP
931
SAPAA
936
GWQSL
941
ETGQN
946
QSDPV
951
GPALN
956
LFGGS
961
TGLGQ
966
WSSSA
971
GGSSG
976
ADLAG
981
ASLWG
986
PPNYS
991
SSLWG
996
VPTVE
1001
DPHRM
1006
GSPAP
1011
LLPGD
1016
LLGGG
1021
SDSI
1026
Mutation Information
DNA mutation:
None
Peptide Range:
514 ~ 538
Mut AA position:
526 (13 in Wild Type peptide)
Alignment
Wild Type:
"SALQQQQQQQQRQPGMKHSPSHPVG
||||||||||||.||||||||||||
Mutant:
SALQQQQQQQQRHPGMKHSPSHPVG"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) TNRC6B

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay