Immunogenicity 6585

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
MKNK2
Transcript ID
NM_199054
HLA INFO
DQA*01:02 / DQB*06:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:02 DQB*06:02
sequence
Full length protein sequence (465 aa)
MVQKK
1
PAELQ
6
GFHRS
11
FKGQN
16
PFELA
21
FSLDQ
26
PDHGD
31
SDFGL
36
QCSAR
41
PDMPA
46
SQPID
51
IPDAK
56
KRGKK
61
KKRGR
66
ATDSF
71
SGRFE
76
DVYQL
81
QEDVL
86
GEGAH
91
ARVQT
96
CINLI
101
TSQEY
106
AVKII
111
EKQPG
116
HIRSR
121
VFREV
126
EMLYQ
131
CQGHR
136
NVLEL
141
IEFFE
146
EEDRF
151
YLVFE
156
KMRGG
161
SILSH
166
IHKRR
171
HFNEL
176
EASVV
181
VQDVA
186
SALDF
191
LHNKG
196
IAHRD
201
LKPEN
206
ILCEH
211
PNQVS
216
PVKIC
221
DFDLG
226
SGIKL
231
NGDCS
236
PISTP
241
ELLTP
246
CGSAE
251
YMAPE
256
VVEAF
261
SEEAS
266
IYDKR
271
CDLWS
276
LGVIL
281
YILLS
286
GYPPF
291
VGRCG
296
SDCGW
301
DRGEA
306
CPACQ
311
NMLFE
316
SIQEG
321
KYEFP
326
DKDWA
331
HISCA
336
AKDLI
341
SKLLV
346
RDAKQ
351
RLSAA
356
QVLQH
361
PWVQG
366
CAPEN
371
TLPTP
376
MVLQR
381
NSCAK
386
DLTSF
391
AAEAI
396
AMNRQ
401
LAQHD
406
EDLAE
411
EEAAG
416
QGQPV
421
LVRAT
426
SRCLQ
431
LSPPS
436
QSKLA
441
QRRQR
446
ASLSS
451
APVVL
456
VGDHA
461
Mutation Information
DNA mutation:
None
Peptide Range:
1 ~ 22
Mut AA position:
10 (10 in Wild Type peptide)
Alignment
Wild Type:
"MVQKKPAELQGFHRSFKGQNPFELA
|||||||||.||||||||||||
Mutant:
MVQKKPAELKGFHRSFKGQNPF---"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) MKNK2

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay