Immunogenicity 6635
Sample ID
3978
Response
Negative
Tumor Type
Bile duct cancer
Gene Symbol
FRAS1
Transcript ID
NM_025074
HLA INFO
B*27:03
TCR INFO
No TCR info found!
Full length protein sequence (4012 aa)
MGVLK
1
VWLGL
6
ALALA
11
EFAVL
16
PHHSE
21
GACVY
26
QDSLL
31
ADATI
36
WKPDS
41
CQSCR
46
CHGDI
51
VICKP
56
AVCRN
61
PQCAF
66
EKGEV
71
LQIAA
76
NQCCP
81
ECVLR
86
TPGSC
91
HHEKK
96
IHEHG
101
TEWAS
106
SPCSV
111
CSCNH
116
GEVRC
121
TPQPC
126
PPLSC
131
GHQEL
136
AFIPE
141
GSCCP
146
VCVGL
151
GKPCS
156
YEGHV
161
FQDGE
166
DWRLS
171
RCAKC
176
LCRNG
181
VAQCF
186
TAQCQ
191
PLFCN
196
QDETV
201
VRVPG
206
KCCPQ
211
CSARS
216
CSAAG
221
QVYEH
226
GEQWS
231
ENACT
236
TCICD
241
RGEVR
246
CHKQA
251
CLPLR
256
CGKGQ
261
SRARR
266
HGQCC
271
EECVS
276
PAGSC
281
SYDGV
286
VRYQD
291
EMWKG
296
SACEF
301
CMCDH
306
GQVTC
311
QTGEC
316
AKVEC
321
ARDEE
326
LIHLD
331
GKCCP
336
ECISR
341
NGYCV
346
YEETG
351
EFMSS
356
NASEV
361
KRIPE
366
GEKWE
371
DGPCK
376
VCECR
381
GAQVT
386
CYEPS
391
CPPCP
396
VGTLA
401
LEVKG
406
QCCPD
411
CTSVH
416
CHPDC
421
LTCSQ
426
SPDHC
431
DLCQD
436
PTKLL
441
QNGWC
446
VHSCG
451
LGFYQ
456
AGSLC
461
LACQP
466
QCSTC
471
TSGLE
476
CSSCQ
481
PPLLM
486
RHGQC
491
VPTCG
496
DGFYQ
501
DRHSC
506
AVCHE
511
SCAGC
516
WGPTE
521
KHCLA
526
CRDPL
531
HVLRD
536
GGCES
541
SCGKG
546
FYNRQ
551
GTCSA
556
CDQSC
561
DSCGP
566
SSPRC
571
LTCTE
576
KTVLH
581
DGKCM
586
SECPG
591
GYYAD
596
ATGRC
601
KVCHN
606
SCASC
611
SGPTP
616
SHCTA
621
CSPPK
626
ALRQG
631
HCLPR
636
CGEGF
641
YSDHG
646
VCKAC
651
HSSCL
656
ACMGP
661
APSHC
666
TGCKK
671
PEEGL
676
QVEQL
681
SDVGI
686
PSGEC
691
LAQCR
696
AHFYL
701
ESTGI
706
CEACH
711
QSCFR
716
CAGKS
721
PHNCT
726
DCGPS
731
HVLLD
736
GQCLS
741
QCPDG
746
YFHQE
751
GSCTE
756
CHPTC
761
RQCHG
766
PLESD
771
CISCY
776
PHISL
781
TNGNC
786
RTSCR
791
EEQFL
796
NLVGY
801
CADCH
806
HLCQH
811
CAADL
816
HNTGS
821
ICLRC
826
QNAHY
831
LLLGD
836
HCVPD
841
CPSGY
846
YAERG
851
ACKKC
856
HSSCR
861
TCQGR
866
GPFSC
871
SSCDT
876
NLVLS
881
HTGTC
886
STTCF
891
PGHYL
896
DDNHV
901
CQPCN
906
THCGS
911
CDSQA
916
SCTSC
921
RDPNK
926
VLLFG
931
ECQYE
936
SCAPQ
941
YYLDF
946
STNTC
951
KECDW
956
SCSAC
961
SGPLK
966
TDCLQ
971
CMDGY
976
VLQDG
981
ACVEQ
986
CLSSF
991
YQDSG
996
LCKNC
1001
DSYCL
1006
QCQGP
1011
HECTR
1016
CKGPF
1021
LLLEA
1026
QCVQE
1031
CGKGY
1036
FADHA
1041
KHKCT
1046
ACPQG
1051
CLQCS
1056
HRDRC
1061
HLCDH
1066
GFFLK
1071
SGLCV
1076
YNCVP
1081
GFSVH
1086
TSNET
1091
CSGKI
1096
HTPSL
1101
HVNGS
1106
LILPI
1111
GSIKP
1116
LDFSL
1121
LNVQD
1126
QEGRV
1131
EDLLF
1136
HVVST
1141
PTNGQ
1146
LVLSR
1151
NGKEV
1156
QLDKA
1161
GRFSW
1166
KDVNE
1171
KKVRF
1176
VHSKE
1181
KLRKG
1186
YLFLK
1191
ISDQQ
1196
FFSEP
1201
QLINI
1206
QAFST
1211
QAPYV
1216
LRNEV
1221
LHISR
1226
GERAT
1231
ITTQM
1236
LDIRD
1241
DDNPQ
1246
DVVIE
1251
IIDPP
1256
LHGQL
1261
LQTLQ
1266
SPATP
1271
IYQFQ
1276
LDELS
1281
RGLLH
1286
YAHDG
1291
SDSTS
1296
DVAVL
1301
QANDG
1306
HSFHN
1311
ILFQV
1316
KTVPQ
1321
NDRGL
1326
QLVAN
1331
SMVWV
1336
PEGGM
1341
LQITN
1346
RILQA
1351
EAPGA
1356
SAEEI
1361
IYKIT
1366
QDYPQ
1371
FGEVV
1376
LLVNM
1381
PADSP
1386
ADEGQ
1391
HLPDG
1396
RTATP
1401
TSTFT
1406
QQDIN
1411
EGIVW
1416
YRHSG
1421
APAQS
1426
DSFRF
1431
EVSSA
1436
SNAQT
1441
RLESH
1446
MFNIA
1451
ILPQT
1456
PEAPK
1461
VSLEA
1466
SLHMT
1471
AREDG
1476
LTVIQ
1481
PHSLS
1486
FINSE
1491
KPSGK
1496
IVYNI
1501
TLPLH
1506
PNQGI
1511
IEHRD
1516
HPHSP
1521
IRYFT
1526
QEDIN
1531
QGKVM
1536
YRPPP
1541
AAPHL
1546
QELMA
1551
FSFAG
1556
LPESV
1561
KFHFT
1566
VSDGE
1571
HTSPE
1576
MVLTI
1581
HLLPS
1586
DQQLP
1591
VFQVT
1596
APRLA
1601
VSPGG
1606
STSVG
1611
LQVVV
1616
RDAET
1621
APKEL
1626
FFELR
1631
RPPQH
1636
GVLLK
1641
HTAEF
1646
RRPMA
1651
TGDTF
1656
TYEDV
1661
EKNAL
1666
QYIHD
1671
GSSTR
1676
EDSME
1681
ISVTD
1686
GLTVT
1691
MLEVR
1696
VEVSL
1701
SEDRG
1706
PRLAA
1711
GSSLS
1716
ITVAS
1721
KSTAI
1726
ITRSH
1731
LAYVD
1736
DSSPD
1741
PEIWI
1746
QLNYL
1751
PSYGT
1756
LLRIS
1761
GSEVE
1766
ELSEV
1771
SNFTM
1776
EDINN
1781
KKIRY
1786
SAVFE
1791
TDGHL
1796
VTDSF
1801
YFSVS
1806
DMDHN
1811
HLDNQ
1816
IFTIM
1821
ITPAE
1826
NPPPV
1831
IAFAD
1836
LITVD
1841
EGGRA
1846
PLSFH
1851
HFFAT
1856
DDDDN
1861
LQRDA
1866
IIKLS
1871
ALPKY
1876
GCIEN
1881
TGTGD
1886
RFGPE
1891
TASDL
1896
EASFP
1901
IQDVL
1906
ENYIY
1911
YFQSV
1916
HESIE
1921
PTHDI
1926
FSFYV
1931
SDGTS
1936
RSEIH
1941
SINIT
1946
IERKN
1951
DEPPR
1956
MTLQP
1961
LRVQL
1966
SSGVV
1971
ISNSS
1976
LSLQD
1981
LDTPD
1986
NELIF
1991
VLTKK
1996
PDHGH
2001
VLWRQ
2006
TASEP
2011
LENGR
2016
VLVQG
2021
STFTY
2026
QDILA
2031
GLVGY
2036
VPSVP
2041
GMVVD
2046
EFQFS
2051
LTDGL
2056
HVDTG
2061
RMKIY
2066
TELPA
2071
SDTPH
2076
LAINQ
2081
GLQLS
2086
AGSVA
2091
RITEQ
2096
HLKVT
2101
DIDSD
2106
DHQVM
2111
YIMKE
2116
DPGAG
2121
RLQMM
2126
KHGNL
2131
EQISI
2136
KGPIR
2141
SFTQA
2146
DISQG
2151
HVEYS
2156
HGTGE
2161
PGGSF
2166
AFKFD
2171
VVDGE
2176
GNRLI
2181
DKSFS
2186
ISILE
2191
DKSPP
2196
VITTN
2201
KGLVL
2206
DENSV
2211
KKITT
2216
LQLSA
2221
TDQDS
2226
GPTEL
2231
IYRIT
2236
RQPQL
2241
GHLEH
2246
AASPG
2251
IQISS
2256
FTQAD
2261
LTSRN
2266
VQYVH
2271
SSEAE
2276
KHSDA
2281
FSFTL
2286
SDGVS
2291
EVTQT
2296
FHITL
2301
HPVDD
2306
SLPVV
2311
QNLGM
2316
RVQEG
2321
MRKTI
2326
TEFEL
2331
KAVDA
2336
DTEAE
2341
SVTFT
2346
IVQPP
2351
RHGTI
2356
ERTSN
2361
GQHFH
2366
LTSTF
2371
TMKDI
2376
YQNRV
2381
SYSHD
2386
GSNSL
2391
KDRFT
2396
FTVSD
2401
GTNPF
2406
FIIEE
2411
GGKEI
2416
MTAAP
2421
QPFRV
2426
DILPV
2431
DDGTP
2436
RIVTN
2441
LGLQW
2446
LEYMD
2451
GKATN
2456
LITKK
2461
ELLTM
2466
DPDTE
2471
DAQLV
2476
YEITT
2481
GPKHG
2486
FVENK
2491
LQPGR
2496
AAATF
2501
TQEDV
2506
NLGLI
2511
RYVLH
2516
KEKIR
2521
EMMDS
2526
FQFLV
2531
KDSKP
2536
NVVSD
2541
NVFHI
2546
QWSLI
2551
SFKYT
2556
SYNVS
2561
EKAGS
2566
VSVTV
2571
QRTGN
2576
LNQYA
2581
IVLCR
2586
TEQGT
2591
ASSSS
2596
RVSSQ
2601
PGQQD
2606
YVEYA
2611
GQVQF
2616
DERED
2621
TKSCT
2626
IVIND
2631
DDVFE
2636
NVESF
2641
TVELS
2646
MPAYA
2651
LLGEF
2656
TQAKV
2661
IINDT
2666
EDEPT
2671
LEFDK
2676
KIYWV
2681
NESAG
2686
FLFAP
2691
IERKG
2696
DASSI
2701
VSAIC
2706
YTVPK
2711
SAMGS
2716
SLYAL
2721
ESGSD
2726
FKSRG
2731
MSAAS
2736
RVIFG
2741
PGVTM
2746
STCDV
2751
MLIDD
2756
SEYEE
2761
EEEFE
2766
IALAD
2771
ASDNA
2776
RIGRV
2781
ATAKV
2786
LISGP
2791
NDAST
2796
VSLGN
2801
TAFTV
2806
SEDAG
2811
TVKIP
2816
VIRHG
2821
TDLST
2826
FASVW
2831
CATRP
2836
SDPAS
2841
ATPGV
2846
DYVPS
2851
SRKVE
2856
FGPGV
2861
IEQYC
2866
TLTIL
2871
DDTQY
2876
PVIEG
2881
LETFV
2886
VFLSS
2891
AQGAE
2896
LTKPF
2901
QAVIA
2906
INDTF
2911
QDVPS
2916
MQFAK
2921
DLLLV
2926
KEKEG
2931
VLHVP
2936
ITRSG
2941
DLSYE
2946
SSVRC
2951
YTQSH
2956
SAQVM
2961
EDFEE
2966
RQNAD
2971
SSRIT
2976
FLKGD
2981
KVKNC
2986
TVYIH
2991
DDSMF
2996
EPEEQ
3001
FRVYL
3006
GLPLG
3011
NHWSG
3016
ARIGK
3021
NNMAT
3026
ITISN
3031
DEDAP
3036
TIEFE
3041
EAAYQ
3046
VREPA
3051
GPDAI
3056
AILNI
3061
KVIRR
3066
GDQNR
3071
TSKVR
3076
CSTRD
3081
GSAQS
3086
GVDYY
3091
PKSRV
3096
LKFSP
3101
GVDHI
3106
FFKVE
3111
ILSNE
3116
DREWH
3121
ESFSL
3126
VLGPD
3131
DPVEA
3136
VLGDV
3141
TTATV
3146
TILDQ
3151
EAAGS
3156
LILPA
3161
PPIVV
3166
TLADY
3171
DHVEE
3176
VTKEG
3181
VKKSP
3186
SPGYP
3191
LVCVT
3196
PCDPH
3201
FPRYA
3206
VMKER
3211
CSEAG
3216
INQTS
3221
VQFSW
3226
EVAAP
3231
TDGNG
3236
ARSPF
3241
ETITD
3246
NTPFT
3251
SVNHM
3256
VLDSI
3261
YFSRR
3266
FHVRC
3271
VAKAV
3276
DKVGH
3281
VGTPL
3286
RSNIV
3291
TIGTD
3296
SAICH
3301
TPVVA
3306
GTSRG
3311
FQAQS
3316
FIATL
3321
KYLDV
3326
KHKEH
3331
PNRIH
3336
ISVQI
3341
PHQDG
3346
MLPLI
3351
STMPL
3356
HNLHF
3361
LLSES
3366
IYRHQ
3371
HVCSN
3376
LVTTY
3381
DLRGI
3386
SEAGF
3391
LDDVV
3396
YDSTA
3401
LGPGY
3406
DRPFQ
3411
FDPSV
3416
REPKT
3421
IQLYK
3426
HLNLK
3431
SCVWT
3436
FDAYY
3441
DMTEL
3446
IDVCG
3451
GSVTA
3456
DFQVR
3461
DSAQS
3466
FLTVH
3471
VPLYV
3476
SYIYV
3481
TAPRG
3486
WASLE
3491
HHTEM
3496
EFSFF
3501
YDTVL
3506
WRTGI
3511
QTDSV
3516
LSARL
3521
QIIRI
3526
YIRED
3531
GRLVI
3536
EFKTH
3541
AKFRG
3546
QFVME
3551
HHTLP
3556
EVKSF
3561
VLTPD
3566
HLGGI
3571
EFDLQ
3576
LLWSA
3581
QTFDS
3586
PHQLW
3591
RATSS
3596
YNRKD
3601
YSGEY
3606
TIYLI
3611
PCTVQ
3616
PTQPW
3621
VDPGE
3626
KPLAC
3631
TAHAP
3636
ERFLI
3641
PIAFQ
3646
QTNRP
3651
VPVVY
3656
SLNTE
3661
FQLCN
3666
NEKVF
3671
LMDPN
3676
TSDMS
3681
LAEMD
3686
YKGAF
3691
SKGQI
3696
LYGRV
3701
LWNPE
3706
QNLNS
3711
AYKLQ
3716
LEKVY
3721
LCTGK
3726
DGYVP
3731
FFDPT
3736
GTIYN
3741
EGPQY
3746
GCIQP
3751
NKHLK
3756
HRFLL
3761
LDRNQ
3766
PEVTD
3771
KYFHD
3776
VPFEA
3781
HFASE
3786
LPDFH
3791
VVSNM
3796
PGVDG
3801
FTLKV
3806
DALYK
3811
VEAGH
3816
QWYLQ
3821
VIYII
3826
GPDTI
3831
SGPRV
3836
QRSLT
3841
APLRR
3846
NRRDL
3851
VEPDG
3856
QLILD
3861
DSLIY
3866
DNEGD
3871
QVKNG
3876
TNMKS
3881
LNLEM
3886
QELAV
3891
AASLS
3896
QTGAS
3901
IGSAL
3906
AAIML
3911
LLLVF
3916
LVACF
3921
INRKC
3926
QKQRK
3931
KKPAE
3936
DILEE
3941
YPLNT
3946
KVEVP
3951
KRHPD
3956
RVEKN
3961
VNRHY
3966
CTVRN
3971
VNILS
3976
EPEAA
3981
YTFKG
3986
AKVKR
3991
LNLEV
3996
RVHNN
4001
LQDGT
4006
EV
4011
Mutation Information
DNA mutation:
None
Peptide Range:
3992 ~ 4012
Mut AA position:
4004 (13 in Wild Type peptide)
Alignment
Wild Type:
"KVKRLNLEVRVHNNLQDGTEV
||||||||||||.||||||||
Mutant:
KVKRLNLEVRVHHNLQDGTEV"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) FRAS1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay