Immunogenicity 7036
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
GRM1
Transcript ID
NM_001278064
HLA INFO
B*40:01
TCR INFO
No TCR info found!
Full length protein sequence (1194 aa)
MVGLL
1
LFFFP
6
AIFLE
11
VSLLP
16
RSPGR
21
KVLLA
26
GASSQ
31
RSVAR
36
MDGDV
41
IIGAL
46
FSVHH
51
QPPAE
56
KVPER
61
KCGEI
66
REQYG
71
IQRVE
76
AMFHT
81
LDKIN
86
ADPVL
91
LPNIT
96
LGSEI
101
RDSCW
106
HSSVA
111
LEQSI
116
EFIRD
121
SLISI
126
RDEKD
131
GINRC
136
LPDGQ
141
SLPPG
146
RTKKP
151
IAGVI
156
GPGSS
161
SVAIQ
166
VQNLL
171
QLFDI
176
PQIAY
181
SATSI
186
DLSDK
191
TLYKY
196
FLRVV
201
PSDTL
206
QARAM
211
LDIVK
216
RYNWT
221
YVSAV
226
HTEGN
231
YGESG
236
MDAFK
241
ELAAQ
246
EGLCI
251
AHSDK
256
IYSNA
261
GEKSF
266
DRLLR
271
KLRER
276
LPKAR
281
VVVCF
286
CEGMT
291
VRGLL
296
SAMRR
301
LGVVG
306
EFSLI
311
GSDGW
316
ADRDE
321
VIEGY
326
EVEAN
331
GGITI
336
KLQSP
341
EVRSF
346
DDYFL
351
KLRLD
356
TNTRN
361
PWFPE
366
FWQHR
371
FQCRL
376
PGHLL
381
ENPNF
386
KRICT
391
GNESL
396
EENYV
401
QDSKM
406
GFVIN
411
AIYAM
416
AHGLQ
421
NMHHA
426
LCPGH
431
VGLCD
436
AMKPI
441
DGSKL
446
LDFLI
451
KSSFI
456
GVSGE
461
EVWFD
466
EKGDA
471
PGRYD
476
IMNLQ
481
YTEAN
486
RYDYV
491
HVGTW
496
HEGVL
501
NIDDY
506
KIQMN
511
KSGVV
516
RSVCS
521
EPCLK
526
GQIKV
531
IRKGE
536
VSCCW
541
ICTAC
546
KENEY
551
VQDEF
556
TCKAC
561
DLGWW
566
PNADL
571
TGCEP
576
IPVRY
581
LEWSN
586
IESII
591
AIAFS
596
CLGIL
601
VTLFV
606
TLIFV
611
LYRDT
616
PVVKS
621
SSREL
626
CYIIL
631
AGIFL
636
GYVCP
641
FTLIA
646
KPTTT
651
SCYLQ
656
RLLVG
661
LSSAM
666
CYSAL
671
VTKTN
676
RIARI
681
LAGSK
686
KKICT
691
RKPRF
696
MSAWA
701
QVIIA
706
SILIS
711
VQLTL
716
VVTLI
721
IMEPP
726
MPILS
731
YPSIK
736
EVYLI
741
CNTSN
746
LGVVA
751
PLGYN
756
GLLIM
761
SCTYY
766
AFKTR
771
NVPAN
776
FNEAK
781
YIAFT
786
MYTTC
791
IIWLA
796
FVPIY
801
FGSNY
806
KIITT
811
CFAVS
816
LSVTV
821
ALGCM
826
FTPKM
831
YIIIA
836
KPERN
841
VRSAF
846
TTSDV
851
VRMHV
856
GDGKL
861
PCRSN
866
TFLNI
871
FRRKK
876
AGAGN
881
ANSNG
886
KSVSW
891
SEPGG
896
GQVPK
901
GQHMW
906
HRLSV
911
HVKTN
916
ETACN
921
QTAVI
926
KPLTK
931
SYQGS
936
GKSLT
941
FSDTS
946
TKTLY
951
NVEEE
956
EDAQP
961
IRFSP
966
PGSPS
971
MVVHR
976
RVPSA
981
ATTPP
986
LPSHL
991
TAEET
996
PLFLA
1001
EPALP
1006
KGLPP
1011
PLQQQ
1016
QQPPP
1021
QQKSL
1026
MDQLQ
1031
GVVSN
1036
FSTAI
1041
PDFHA
1046
VLAGP
1051
GGPGN
1056
GLRSL
1061
YPPPP
1066
PPQHL
1071
QMLPL
1076
QLSTF
1081
GEELV
1086
SPPAD
1091
DDDDS
1096
ERFKL
1101
LQEYV
1106
YEHER
1111
EGNTE
1116
EDELE
1121
EEEED
1126
LQAAS
1131
KLTPD
1136
DSPAL
1141
TPPSP
1146
FRDSV
1151
ASGSS
1156
VPSSP
1161
VSESV
1166
LCTPP
1171
NVSYA
1176
SVILR
1181
DYKQS
1186
SSTL
1191
Mutation Information
DNA mutation:
None
Peptide Range:
437 ~ 461
Mut AA position:
449 (13 in Wild Type peptide)
Alignment
Wild Type:
"GLCDAMKPIDGSKLLDFLIKSSFIG
||||||||||||.||||||||||||
Mutant:
GLCDAMKPIDGSMLLDFLIKSSFIG"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) GRM1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay