Immunogenicity 7189
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
WNK1
Transcript ID
NM_213655
HLA INFO
C*07:02
TCR INFO
No TCR info found!
Full length protein sequence (2634 aa)
MSGGA
1
AEKQS
6
STPGS
11
LFLSP
16
PAPAP
21
KNGSS
26
SDSSV
31
GEKLG
36
AAAAD
41
AVTGR
46
TEEYR
51
RRRHT
56
MDKDS
61
RGAAA
66
TTTTT
71
EHRFF
76
RRSVI
81
CDSNA
86
TALEL
91
PGLPL
96
SLPQP
101
SIPAA
106
VPQSA
111
PPEPH
116
REETV
121
TATAT
126
SQVAQ
131
QPPAA
136
AAPGE
141
QAVAG
146
PAPST
151
VPSST
156
SKDRP
161
VSQPS
166
LVGSK
171
EEPPP
176
ARSGS
181
GGGSA
186
KEPQE
191
ERSQQ
196
QDDIE
201
ELETK
206
AVGMS
211
NDGRF
216
LKFDI
221
EIGRG
226
SFKTV
231
YKGLD
236
TETTV
241
EVAWC
246
ELQDR
251
KLTKS
256
ERQRF
261
KEEAE
266
MLKGL
271
QHPNI
276
VRFYD
281
SWEST
286
VKGKK
291
CIVLV
296
TELMT
301
SGTLK
306
TYLKR
311
FKVMK
316
IKVLR
321
SWCRQ
326
ILKGL
331
QFLHT
336
RTPPI
341
IHRDL
346
KCDNI
351
FITGP
356
TGSVK
361
IGDLG
366
LATLK
371
RASFA
376
KSVIG
381
TPEFM
386
APEMY
391
EEKYD
396
ESVDV
401
YAFGM
406
CMLEM
411
ATSEY
416
PYSEC
421
QNAAQ
426
IYRRV
431
TSGVK
436
PASFD
441
KVAIP
446
EVKEI
451
IEGCI
456
RQNKD
461
ERYSI
466
KDLLN
471
HAFFQ
476
EETGV
481
RVELA
486
EEDDG
491
EKIAI
496
KLWLR
501
IEDIK
506
KLKGK
511
YKDNE
516
AIEFS
521
FDLER
526
DVPED
531
VAQEM
536
VESGY
541
VCEGD
546
HKTMA
551
KAIKD
556
RVSLI
561
KRKRE
566
QRQLV
571
REEQE
576
KKKQE
581
ESSLK
586
QQVEQ
591
SSASQ
596
TGIKQ
601
LPSAS
606
TGIPT
611
ASTTS
616
ASVST
621
QVEPE
626
EPEAD
631
QHQQL
636
QYQQP
641
SISVL
646
SDGTV
651
DSGQG
656
SSVFT
661
ESRVS
666
SQQTV
671
SYGSQ
676
HEQAH
681
STGTV
686
PGHIP
691
STVQA
696
QSQPH
701
GVYPP
706
SSVPR
711
RGRSM
716
SVCVP
721
IFLLL
726
PLCPA
731
SLPVL
736
FHPTA
741
STVCT
746
SFSFP
751
PPDCP
756
EETFA
761
EKLSK
766
ALESV
771
LPMHS
776
ASQRK
781
HRRSS
786
LPSLF
791
VSTPQ
796
SMAHP
801
CGGTP
806
TYPES
811
QIFFP
816
TIHER
821
PVSFS
826
PPPTC
831
PPKVA
836
ISQRR
841
KSTSF
846
LEAQT
851
HHFQP
856
LLRTV
861
GQSLL
866
PPGGS
871
PTNWT
876
PEAVV
881
MLGTT
886
ASRVT
891
GESCE
896
IQVHP
901
MFEPS
906
QVYSD
911
YRPGL
916
VLPEE
921
AHYFI
926
PQEAV
931
YVAGV
936
HYQAR
941
VAEQY
946
EGIPY
951
NSSVL
956
SSPMK
961
QIPEQ
966
KPVQG
971
GPTSS
976
SVFEF
981
PSGQA
986
FLVGH
991
LQNLR
996
LDSGL
1001
GPGSP
1006
LSSIS
1011
APIST
1016
DATRL
1021
KFHPV
1026
FVPHS
1031
APAVL
1036
THNNE
1041
SRSNC
1046
VFEFH
1051
VHTPS
1056
SSSGE
1061
GGGIL
1066
PQRVY
1071
RNRQV
1076
AVDLN
1081
QEELP
1086
PQSVG
1091
LHGYL
1096
QPVTE
1101
EKHNY
1106
HAPEL
1111
TVSVV
1116
EPIGQ
1121
NWPIG
1126
SPEYS
1131
SDSSQ
1136
ITSSD
1141
PSDFQ
1146
SPPPT
1151
GGAAA
1156
PFGSD
1161
VSMPF
1166
IHLPQ
1171
TVLQE
1176
SPLFF
1181
CFPQG
1186
TTSQQ
1191
VLTAS
1196
FSSGG
1201
SALHP
1206
QAQGQ
1211
SQGQP
1216
SSSSL
1221
TGVSS
1226
SQPIQ
1231
HPQQQ
1236
QGIQQ
1241
TAPPQ
1246
QTVQY
1251
SLSQT
1256
STSSE
1261
ATTAQ
1266
PVSQP
1271
QAPQV
1276
LPQVS
1281
AGKQS
1286
TQGVS
1291
QVAPA
1296
EPVAV
1301
AQTQA
1306
TQPTT
1311
LASSV
1316
DSAHS
1321
DVASG
1326
MSDGN
1331
ENVPS
1336
SSGRH
1341
EGRTT
1346
KRHYR
1351
KSVRS
1356
RSRHE
1361
KTSRP
1366
KLRIL
1371
NVSNK
1376
GDRVV
1381
ECQLE
1386
THNRK
1391
MVTFK
1396
FDLDG
1401
DNPEE
1406
IATIM
1411
VNNDF
1416
ILAIE
1421
RESFV
1426
DQVRE
1431
IIEKA
1436
DEMLS
1441
EDVSV
1446
EPEGD
1451
QGLES
1456
LQGKD
1461
DYGFS
1466
GSQKL
1471
EGEFK
1476
QPIPA
1481
SSMPQ
1486
QIGIP
1491
TSSLT
1496
QVVHS
1501
AGRRF
1506
IVSPV
1511
PESRL
1516
RESKV
1521
FPSEI
1526
TDTVA
1531
ASTAQ
1536
SPGMN
1541
LSHSA
1546
SSLSL
1551
QQAFS
1556
ELRRA
1561
QMTEG
1566
PNTAP
1571
PNFSH
1576
TGPTF
1581
PVVPP
1586
FLSSI
1591
AGVPT
1596
TAAAT
1601
APVPA
1606
TSSPP
1611
NDIST
1616
SVIQS
1621
EVTVP
1626
TEEGI
1631
AGVAT
1636
STGVV
1641
TSGGL
1646
PIPPV
1651
SESPV
1656
LSSVV
1661
SSITI
1666
PAVVS
1671
ISTTS
1676
PSLQV
1681
PTSTS
1686
EIVVS
1691
STALY
1696
PSVTV
1701
SATSA
1706
SAGGS
1711
TATPG
1716
PKPPA
1721
VVSQQ
1726
AAGST
1731
TVGAT
1736
LTSVS
1741
TTTSF
1746
PSTAS
1751
QLCIQ
1756
LSSST
1761
STPTL
1766
AETVV
1771
VSAHS
1776
LDKTS
1781
HSSTT
1786
GLAFS
1791
LSAPS
1796
SSSSP
1801
GAGVS
1806
SYISQ
1811
PGGLH
1816
PLVIP
1821
SVIAS
1826
TPILP
1831
QAAGP
1836
TSTPL
1841
LPQVP
1846
SIPPL
1851
VQPVA
1856
NVPAV
1861
QQTLI
1866
HSQPQ
1871
PALLP
1876
NQPHT
1881
HCPEV
1886
DSDTQ
1891
PKAPG
1896
IDDIK
1901
TLEEK
1906
LRSLF
1911
SEHSS
1916
SGAQH
1921
ASVSL
1926
ETSLV
1931
IESTV
1936
TPGIP
1941
TTAVA
1946
PSKLL
1951
TSTTS
1956
TCLPP
1961
TNLPL
1966
GTVAL
1971
PVTPV
1976
VTPGQ
1981
VSTPV
1986
STTTS
1991
GVKPG
1996
TAPSK
2001
PPLTK
2006
APVLP
2011
VGTEL
2016
PAGTL
2021
PSEQL
2026
PPFPG
2031
PSLTQ
2036
SQQPL
2041
EDLDA
2046
QLRRT
2051
LSPEM
2056
ITVTS
2061
AVGPV
2066
SMAAP
2071
TAITE
2076
AGTQP
2081
QKGVS
2086
QVKEG
2091
PVLAT
2096
SSGAG
2101
VFKMG
2106
RFQVS
2111
VAADG
2116
AQKEG
2121
KNKSE
2126
DAKSV
2131
HFESS
2136
TSESS
2141
VLSSS
2146
SPEST
2151
LVKPE
2156
PNGIT
2161
IPGIS
2166
SDVPE
2171
SAHKT
2176
TASEA
2181
KSDTG
2186
QPTKV
2191
GRFQV
2196
TTTAN
2201
KVGRF
2206
SVSKT
2211
EDKIT
2216
DTKKE
2221
GPVAS
2226
PPFMD
2231
LEQAV
2236
LPAVI
2241
PKKEK
2246
PELSE
2251
PSHLN
2256
GPSSD
2261
PEAAF
2266
LSRDV
2271
DDGSG
2276
SPHSP
2281
HQLSS
2286
KSLPS
2291
QNLSQ
2296
SLSNS
2301
FNSSY
2306
MSSDN
2311
ESDIE
2316
DEDLK
2321
LELRR
2326
LRDKH
2331
LKEIQ
2336
DLQSR
2341
QKHEI
2346
ESLYT
2351
KLGKV
2356
PPAVI
2361
IPPAA
2366
PLSGR
2371
RRRPT
2376
KSKGS
2381
KSSRS
2386
SSLGN
2391
KSPQL
2396
SGNLS
2401
GQSAA
2406
SVLHP
2411
QQTLH
2416
PPGNI
2421
PESGQ
2426
NQLLQ
2431
PLKPS
2436
PSSDN
2441
LYSAF
2446
TSDGA
2451
ISVPS
2456
LSAPG
2461
QGTSS
2466
TNTVG
2471
ATVNS
2476
QAAQA
2481
QPPAM
2486
TSSRK
2491
GTFTD
2496
DLHKL
2501
VDNWA
2506
RDAMN
2511
LSGRR
2516
GSKGH
2521
MNYEG
2526
PGMAR
2531
KFSAP
2536
GQLCI
2541
SMTSN
2546
LGGSA
2551
PISAA
2556
SATSL
2561
GHFTK
2566
SMCPP
2571
QQYGF
2576
PATPF
2581
GAQWS
2586
GTGGP
2591
APQPL
2596
GQFQP
2601
VGTAS
2606
LQNFN
2611
ISNLQ
2616
KSISN
2621
PPGSN
2626
LRTT
2631
Mutation Information
DNA mutation:
None
Peptide Range:
2520 ~ 2544
Mut AA position:
2532 (13 in Wild Type peptide)
Alignment
Wild Type:
"RGSKGHMNYEGPGMARKFSAPGQLC
||||||||||||.||||||||||||
Mutant:
RGSKGHMNYEGPAMARKFSAPGQLC"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) WNK1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay