Immunogenicity 7405
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
NOS1
Transcript ID
NM_001204218
HLA INFO
C*07:02
TCR INFO
No TCR info found!
Full length protein sequence (1468 aa)
MEDHM
1
FGVQQ
6
IQPNV
11
ISVRL
16
FKRKV
21
GGLGF
26
LVKER
31
VSKPP
36
VIISD
41
LIRGG
46
AAEQS
51
GLIQA
56
GDIIL
61
AVNGR
66
PLVDL
71
SYDSA
76
LEVLR
81
GIASE
86
THVVL
91
ILRGP
96
EGFTT
101
HLETT
106
FTGDG
111
TPKTI
116
RVTQP
121
LGPPT
126
KAVDL
131
SHQPP
136
AGKEQ
141
PLAVD
146
GASGP
151
GNGPQ
156
HAYDD
161
GQEAG
166
SLPHA
171
NGLAP
176
RPPGQ
181
DPAKK
186
ATRVS
191
LQGRG
196
ENNEL
201
LKEIE
206
PVLSL
211
LTSGS
216
RGVKG
221
GAPAK
226
AEMKD
231
MGIQV
236
DRDLD
241
GKSHK
246
PLPLG
251
VENDR
256
VFNDL
261
WGKGN
266
VPVVL
271
NNPYS
276
EKEQP
281
PTSGK
286
QSPTK
291
NGSPS
296
KCPRF
301
LKVKN
306
WETEV
311
VLTDT
316
LHLKS
321
TLETG
326
CTEYI
331
CMGSI
336
MHPSQ
341
HARRP
346
EDVRT
351
KGQLF
356
PLAKE
361
FIDQY
366
YSSIK
371
RFGSK
376
AHMER
381
LEEVN
386
KEIDT
391
TSTYQ
396
LKDTE
401
LIYGA
406
KHAWR
411
NASRC
416
VGRIQ
421
WSKLQ
426
VFDAR
431
DCTTA
436
HGMFN
441
YICNH
446
VKYAT
451
NKGNL
456
RSAIT
461
IFPQR
466
TDGKH
471
DFRVW
476
NSQLI
481
RYAGY
486
KQPDG
491
STLGD
496
PANVQ
501
FTEIC
506
IQQGW
511
KPPRG
516
RFDVL
521
PLLLQ
526
ANGND
531
PELFQ
536
IPPEL
541
VLEVP
546
IRHPK
551
FEWFK
556
DLGLK
561
WYGLP
566
AVSNM
571
LLEIG
576
GLEFS
581
ACPFS
586
GWYMG
591
TEIGV
596
RDYCD
601
NSRYN
606
ILEEV
611
AKKMN
616
LDMRK
621
TSSLW
626
KDQAL
631
VEINI
636
AVLYS
641
FQSDK
646
VTIVD
651
HHSAT
656
ESFIK
661
HMENE
666
YRCRG
671
GCPAD
676
WVWIV
681
PPMSG
686
SITPV
691
FHQEM
696
LNYRL
701
TPSFE
706
YQPDP
711
WNTHV
716
WKGTN
721
GTPTK
726
RRAIG
731
FKKLA
736
EAVKF
741
SAKLM
746
GQAMA
751
KRVKA
756
TILYA
761
TETGK
766
SQAYA
771
KTLCE
776
IFKHA
781
FDAKV
786
MSMEE
791
YDIVH
796
LEHET
801
LVLVV
806
TSTFG
811
NGDPP
816
ENGEK
821
FGCAL
826
MEMRH
831
PNSVQ
836
EERKY
841
PEPLR
846
FFPRK
851
GPPLP
856
NGDTE
861
VHGLA
866
AARDS
871
QHRSY
876
KVRFN
881
SVSSY
886
SDSQK
891
SSGDG
896
PDLRD
901
NFESA
906
GPLAN
911
VRFSV
916
FGLGS
921
RAYPH
926
FCAFG
931
HAVDT
936
LLEEL
941
GGERI
946
LKMRE
951
GDELC
956
GQEEA
961
FRTWA
966
KKVFK
971
AACDV
976
FCVGD
981
DVNIE
986
KANNS
991
LISND
996
RSWKR
1001
NKFRL
1006
TFVAE
1011
APELT
1016
QGLSN
1021
VHKKR
1026
VSAAR
1031
LLSRQ
1036
NLQSP
1041
KSSRS
1046
TIFVR
1051
LHTNG
1056
SQELQ
1061
YQPGD
1066
HLGVF
1071
PGNHE
1076
DLVNA
1081
LIERL
1086
EDAPP
1091
VNQMV
1096
KVELL
1101
EERNT
1106
ALGVI
1111
SNWTD
1116
ELRLP
1121
PCTIF
1126
QAFKY
1131
YLDIT
1136
TPPTP
1141
LQLQQ
1146
FASLA
1151
TSEKE
1156
KQRLL
1161
VLSKG
1166
LQEYE
1171
EWKWG
1176
KNPTI
1181
VEVLE
1186
EFPSI
1191
QMPAT
1196
LLLTQ
1201
LSLLQ
1206
PRYYS
1211
ISSSP
1216
DMYPD
1221
EVHLT
1226
VAIVS
1231
YRTRD
1236
GEGPI
1241
HHGVC
1246
SSWLN
1251
RIQAD
1256
ELVPC
1261
FVRGA
1266
PSFHL
1271
PRNPQ
1276
VPCIL
1281
VGPGT
1286
GIAPF
1291
RSFWQ
1296
QRQFD
1301
IQHKG
1306
MNPCP
1311
MVLVF
1316
GCRQS
1321
KIDHI
1326
YREET
1331
LQAKN
1336
KGVFR
1341
ELYTA
1346
YSREP
1351
DKPKK
1356
YVQDI
1361
LQEQL
1366
AESVY
1371
RALKE
1376
QGGHI
1381
YVCGD
1386
VTMAA
1391
DVLKA
1396
IQRIM
1401
TQQGK
1406
LSAED
1411
AGVFI
1416
SRMRD
1421
DNRYH
1426
EDIFG
1431
VTLRT
1436
YEVTN
1441
RLRSE
1446
SIAFI
1451
EESKK
1456
DTDEV
1461
FSS
1466
Mutation Information
DNA mutation:
None
Peptide Range:
23 ~ 47
Mut AA position:
35 (13 in Wild Type peptide)
Alignment
Wild Type:
"RKVGGLGFLVKERVSKPPVIISDLI
||||||||||||.||||||||||||
Mutant:
RKVGGLGFLVKEWVSKPPVIISDLI"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) NOS1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay