Immunogenicity 7413

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
SCUBE2
Transcript ID
NM_001170690
HLA INFO
DRB*15:02
TCR INFO

No TCR info found!

T cell Tumor cell DRB*15:02
sequence
Full length protein sequence (807 aa)
MGVAG
1
RNRPG
6
AAWAV
11
LLLLL
16
LLPPL
21
LLLAG
26
AVPPG
31
RGRAA
36
GPQED
41
VDECA
46
QGLDD
51
CHADA
56
LCQNT
61
PTSYK
66
CSCKP
71
GYQGE
76
GRQCE
81
DIDEC
86
GNELN
91
GGCVH
96
DCLNI
101
PGNYR
106
CTCFD
111
GFMLA
116
HDGHN
121
CLDVD
126
ECLEN
131
NGGCQ
136
HTCVN
141
VMGSY
146
ECCCK
151
EGFFL
156
SDNQH
161
TCIHR
166
SEEGL
171
SCMNK
176
DHGCS
181
HICKE
186
APRGS
191
VACEC
196
RPGFE
201
LAKNQ
206
RDCIL
211
TCNHG
216
NGGCQ
221
HSCDD
226
TADGP
231
ECSCH
236
PQYKM
241
HTDGR
246
SCLER
251
EDTVL
256
EVTES
261
NTTSV
266
VDGDK
271
RVKRR
276
LLMET
281
CAVNN
286
GGCDR
291
TCKDT
296
STGVH
301
CSCPV
306
GFTLQ
311
LDGKT
316
CKDID
321
ECQTR
326
NGGCD
331
HFCKN
336
IVGSF
341
DCGCK
346
KGFKL
351
LTDEK
356
SCQDV
361
DECSL
366
DRTCD
371
HSCIN
376
HPGTF
381
ACACN
386
RGYTL
391
YGFTH
396
CGDTN
401
ECSIN
406
NGGCQ
411
QVCVN
416
TVGSY
421
ECQCH
426
PGYKL
431
HWNKK
436
DCVAS
441
CDLSC
446
IVKRT
451
EKRLR
456
KAIRT
461
LRKAV
466
HREQF
471
HLQLS
476
GMNLD
481
VAKKP
486
PRTSE
491
RQAES
496
CGVGQ
501
GHAEN
506
QCVSC
511
RAGTY
516
YDGAR
521
ERCIL
526
CPNGT
531
FQNEE
536
GQMTC
541
EPCPR
546
PGNSG
551
ALKTP
556
EAWNM
561
SECGG
566
LCQPG
571
EYSAD
576
GFAPC
581
QLCAL
586
GTFQP
591
EAGRT
596
SCFPC
601
GGGLA
606
TKHQG
611
ATSFQ
616
DCETR
621
VQCSP
626
GHFYN
631
TTTHR
636
CIRCP
641
VGTYQ
646
PEFGK
651
NNCVS
656
CPGNT
661
TTDFD
666
GSTNI
671
TQCKT
676
SSNSV
681
TTYET
686
CQTYE
691
RPIAF
696
TSRSK
701
KLWIQ
706
FKSNE
711
GNSAR
716
GFQVP
721
YVTYD
726
EDYQE
731
LIEDI
736
VRDGR
741
LYASE
746
NHQEI
751
LKDKK
756
LIKAL
761
FDVLA
766
HPQNY
771
FKYTA
776
QESRE
781
MFPRS
786
FIRLL
791
RSKVS
796
RFLRP
801
YK
806
Mutation Information
DNA mutation:
None
Peptide Range:
444 ~ 468
Mut AA position:
456 (13 in Wild Type peptide)
Alignment
Wild Type:
"ASCDLSCIVKRTEKRLRKAIRTLRK
||||||||||||.||||||||||||
Mutant:
ASCDLSCIVKRTKKRLRKAIRTLRK"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) SCUBE2

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay