Immunogenicity 746

summary
Sample ID
3978
Response
Negative
Tumor Type
Bile duct cancer
Gene Symbol
KCNH2
Transcript ID
ENST00000392968
HLA INFO
DQA*03:01 / DQB*03:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*03:01 DQB*03:02
sequence
Full length protein sequence (1063 aa)
MSSHS
1
AGSCF
6
LCLVD
11
VVPVK
16
NEDGA
21
VIMFI
26
LNFEV
31
VMEKD
36
MVGSP
41
AHDTN
46
HRGPP
51
TSWLA
56
PGRAK
61
TFRLK
66
LPALL
71
ALTAR
76
ESSVR
81
SGGAG
86
GAGAP
91
GAVVV
96
DVDLT
101
PAAPS
106
SESLA
111
LDEVT
116
AMDNH
121
VAGLG
126
PAEER
131
RALVG
136
PGSPP
141
RSAPG
146
QLPSP
151
RAHSL
156
NPDAS
161
GSSCS
166
LARTR
171
SRESC
176
ASVRR
181
ASSAD
186
DIEAM
191
RAGVL
196
PPPPR
201
HASTG
206
AMHPL
211
RSGLL
216
NSTSD
221
SDLVR
226
YRTIS
231
KIPQI
236
TLNFV
241
DLKGD
246
PFLAS
251
PTSDR
256
EIIAP
261
KIKER
266
THNVT
271
EKVTQ
276
VLSLG
281
ADVLP
286
EYKLQ
291
APRIH
296
RWTIL
301
HYSPF
306
KAVWD
311
WLILL
316
LVIYT
321
AVFTP
326
YSAAF
331
LLKET
336
EEGPP
341
ATECG
346
YACQP
351
LAVVD
356
LIVDI
361
MFIVD
366
ILINF
371
RTTYV
376
NANEE
381
VVSHP
386
GRIAV
391
HYFKG
396
WFLID
401
MVAAI
406
PFDLL
411
IFGSG
416
SEELI
421
GLLKT
426
ARLLR
431
LVRVA
436
RKLDR
441
YSEYG
446
AAVLF
451
LLMCT
456
FALIA
461
HWLAC
466
IWYAI
471
GNMEQ
476
PHMDS
481
RIGWL
486
HNLGD
491
QIGKP
496
YNSSG
501
LGGPS
506
IKDKY
511
VTALY
516
FTFSS
521
LTSVG
526
FGNVS
531
PNTNS
536
EKIFS
541
ICVML
546
IGSLM
551
YASIF
556
GNVSA
561
IIQRL
566
YSGTA
571
RYHTQ
576
MLRVR
581
EFIRF
586
HQIPN
591
PLRQR
596
LEEYF
601
QHAWS
606
YTNGI
611
DMNAV
616
LKGFP
621
ECLQA
626
DICLH
631
LNRSL
636
LQHCK
641
PFRGA
646
TKGCL
651
RALAM
656
KFKTT
661
HAPPG
666
DTLVH
671
AGDLL
676
TALYF
681
ISRGS
686
IEILR
691
GDVVV
696
AILGK
701
NDIFG
706
EPLNL
711
YARPG
716
KSNGD
721
VRALT
726
YCDLH
731
KIHRD
736
DLLEV
741
LDMYP
746
EFSDH
751
FWSSL
756
EITFN
761
LRDTN
766
MIPGS
771
PGSTE
776
LEGGF
781
SRQRK
786
RKLSF
791
RRRTD
796
KDTEQ
801
PGEVS
806
ALGPG
811
RAGAG
816
PSSRG
821
RPGGP
826
WGESP
831
SSGPS
836
SPESS
841
EDEGP
846
GRSSS
851
PLRLV
856
PFSSP
861
RPPGE
866
PPGGE
871
PLMED
876
CEKSS
881
DTCNP
886
LSGAF
891
SGVSN
896
IFSFW
901
GDSRG
906
RQYQE
911
LPRCP
916
APTPS
921
LLNIP
926
LSSPG
931
RRPRG
936
DVESR
941
LDALQ
946
RQLNR
951
LETRL
956
SADMA
961
TVLQL
966
LQRQM
971
TLVPP
976
AYSAV
981
TTPGP
986
GPTST
991
SPLLP
996
VSPLP
1001
TLTLD
1006
SLSQV
1011
SQFMA
1016
CEELP
1021
PGAPE
1026
LPQEG
1031
PTRRL
1036
SLPGQ
1041
LGALT
1046
SQPLH
1051
RHGSD
1056
PGS
1061
Mutation Information
DNA mutation:
None
Peptide Range:
303 ~ 327
Mut AA position:
315 (13 in Wild Type peptide)
Alignment
Wild Type:
"TILHYSPFKAVWDWLILLLVIYTAV
||||||||||||.||||||||||||
Mutant:
TILHYSPFKAVWNWLILLLVIYTAV"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) KCNH2

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay