Immunogenicity 7490

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
DENND2A
Transcript ID
NM_015689
HLA INFO
B*07:02
TCR INFO

No TCR info found!

T cell Tumor cell B*07:02
sequence
Full length protein sequence (1009 aa)
MDMFS
1
LDMII
6
SDPAA
11
EASRA
16
GKKQL
21
RGVQN
26
PCPSA
31
RARPR
36
HKSLN
41
IKDKI
46
SEWEG
51
KKEVP
56
TPAPS
61
RRADG
66
QEDYL
71
PSSTV
76
ERRSS
81
DGVRT
86
QVTEA
91
KNGMR
96
PGTES
101
TEKER
106
NKGAV
111
NVGGQ
116
DPEPG
121
QDLSQ
126
PEREV
131
DPSWG
136
RGREP
141
RLGKL
146
RFQND
151
PLSVL
156
KQVKK
161
LEQAL
166
KDGSA
171
GLDPQ
176
LPGTC
181
YSPHC
186
PPDKA
191
EAGST
196
LPENL
201
GGGSG
206
SEVSQ
211
RVHPS
216
DLEGR
221
EPTPE
226
LVEDR
231
KGSCR
236
RPWDR
241
SLENV
246
YRGSE
251
GSPTK
256
PFINP
261
LPKPR
266
RTFKH
271
AGEGD
276
KDGKP
281
GIGFR
286
KEKRN
291
LPPLP
296
SLPPP
301
PLPSS
306
PPPSS
311
VNRRL
316
WTGRQ
321
KSSAD
326
HRKSY
331
EFEDL
336
LQSSS
341
ESSRV
346
DWYAQ
351
TKLGL
356
TRTLS
361
EENVY
366
EDILD
371
PPMKE
376
NPYED
381
IELHG
386
RCLGK
391
KCVLN
396
FPASP
401
TSSIP
406
DTLTK
411
QSLSK
416
PAFFR
421
QNSER
426
RNFKL
431
LDTRK
436
LSRDG
441
TGSPS
446
KISPP
451
STPSS
456
PDDIF
461
FNLGD
466
PQNGR
471
KKRKI
476
PKLVL
481
RINAI
486
YEVRR
491
GKKRV
496
KRLSQ
501
SMESN
506
SGKVT
511
DENSE
516
SDSDT
521
EEKLK
526
AHSQR
531
LVNVK
536
SRLKQ
541
APRYP
546
SLARE
551
LIEYQ
556
ERQLF
561
EYFVV
566
VSLHK
571
KQAGA
576
AYVPE
581
LTQQF
586
PLKLE
591
RSFKF
596
MREAE
601
DQLKA
606
IPQFC
611
FPDAK
616
DWVPV
621
QQFTS
626
ETFSF
631
VLTGE
636
DGSRR
641
FGYCR
646
RLLPG
651
GKGKR
656
LPEVY
661
CIVSR
666
LGCFS
671
LFSRI
676
LDEVE
681
KRRGI
686
SPALV
691
QPLMR
696
SVMEA
701
PFPAL
706
GKTIL
711
VKNFL
716
PGSGT
721
EVIEL
726
CRPLD
731
SRLEH
736
VDFES
741
LFSSL
746
SVRHL
751
VCVFA
756
SLLLE
761
RRVIF
766
IADKL
771
SILSK
776
CCHAM
781
VALIY
786
PFAWQ
791
HTYIP
796
VLPPA
801
MVDIV
806
CSPTP
811
FLIGL
816
LSSSL
821
PLLRE
826
LPLEE
831
VLVVD
836
LVNSR
841
FLRQM
846
DDEDS
851
ILPRK
856
LQVAL
861
EHILE
866
QRNEL
871
ACEQD
876
EGPLD
881
GRHGP
886
ESSPL
891
NEVVS
896
EAFVR
901
FFVEI
906
VGHYS
911
LFLTS
916
GEREE
921
RTLQR
926
EAFRK
931
AVSSK
936
SLRHF
941
LEVFM
946
ETQMF
951
RGFIQ
956
ERELR
961
RQDAK
966
GLFEV
971
RAQEY
976
LETLP
981
SGEHS
986
GVNKF
991
LKGLG
996
NKMKF
1001
LHKK
1006
Mutation Information
DNA mutation:
None
Peptide Range:
267 ~ 291
Mut AA position:
279 (13 in Wild Type peptide)
Alignment
Wild Type:
"PKPRRTFKHAGEGDKDGKPGIGFRK
||||||||||||.||||||||||||
Mutant:
PKPRRTFKHAGEEDKDGKPGIGFRK"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) DENND2A

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay