Immunogenicity 7671

summary
Sample ID
3948
Response
Negative
Tumor Type
Esophageal cancer
Gene Symbol
SEMA3E
Transcript ID
NM_001178129
HLA INFO
DRB*15:01
TCR INFO

No TCR info found!

T cell Tumor cell DRB*15:01
sequence
Full length protein sequence (715 aa)
MLLDE
1
YQERL
6
FVGGR
11
DLVYS
16
LSLER
21
ISDGY
26
KEIHW
31
PSTAL
36
KMEEC
41
IMKGK
46
DAGEC
51
ANYVR
56
VLHHY
61
NRTHL
66
LTCGT
71
GAFDP
76
VCAFI
81
RVGYH
86
LEDPL
91
FHLES
96
PRSER
101
GRGRC
106
PFDPS
111
SSFIS
116
TLIGS
121
ELFAG
126
LYSDY
131
WSRDA
136
AIFRS
141
MGRLA
146
HIRTE
151
HDDER
156
LLKEP
161
KFVGS
166
YMIPD
171
NEDRD
176
DNKVY
181
FFFTE
186
KALEA
191
ENNAH
196
AIYTR
201
VGRLC
206
VNDVG
211
GQRIL
216
VNKWS
221
TFLKA
226
RLVCS
231
VPGMN
236
GIDTY
241
FDELE
246
DVFLL
251
PTRDH
256
KNPVI
261
FGLFN
266
TTSNI
271
FRGHA
276
ICVYH
281
MSSIR
286
AAFNG
291
PYAHK
296
EGPEY
301
HWSVY
306
EGKVP
311
YPRPG
316
SCASK
321
VNGGR
326
YGTTK
331
DYPDD
336
AIRFA
341
RSHPL
346
MYQAI
351
KPAHK
356
KPILV
361
KTDGK
366
YNLKQ
371
IAVDR
376
VEAED
381
GQYDV
386
LFIGT
391
DNGIV
396
LKVIT
401
IYNQE
406
MESME
411
EVILE
416
ELQIF
421
KDPVP
426
IISME
431
ISSKR
436
QQLYI
441
GSASA
446
VAQVR
451
FHHCD
456
MYGSA
461
CADCC
466
LARDP
471
YCAWD
476
GISCS
481
RYYPT
486
GTHAK
491
RRFRR
496
QDVRH
501
GNAAQ
506
QCFGQ
511
QFVGD
516
ALDKT
521
EEHLA
526
YGIEN
531
NSTLL
536
ECTPR
541
SLQAK
546
VIWFV
551
QKGRE
556
TRKEE
561
VKTDD
566
RVVKM
571
DLGLL
576
FLRLH
581
KSDAG
586
TYFCQ
591
TVEHS
596
FVHTV
601
RKITL
606
EVVEE
611
EKVED
616
MFNKD
621
DEEDR
626
HHRMP
631
CPAQS
636
SISQG
641
AKPWY
646
KEFLQ
651
LIGYS
656
NFQRV
661
EEYCE
666
KVWCT
671
DRKRK
676
KLKMS
681
PSKWK
686
YANPQ
691
EKKLR
696
SKPEH
701
YRLPR
706
HTLDS
711
Mutation Information
DNA mutation:
None
Peptide Range:
579 ~ 603
Mut AA position:
591 (13 in Wild Type peptide)
Alignment
Wild Type:
"LLFLRLHKSDAGTYFCQTVEHSFVH
||||||||||||.||||||||||||
Mutant:
LLFLRLHKSDAGSYFCQTVEHSFVH"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) SEMA3E

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay