Immunogenicity 848
Sample ID
3971
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
BRCA2
Transcript ID
ENST00000380152
HLA INFO
B*08:01
TCR INFO
No TCR info found!
Full length protein sequence (3418 aa)
MPIGS
1
KERPT
6
FFEIF
11
KTRCN
16
KADLG
21
PISLN
26
WFEEL
31
SSEAP
36
PYNSE
41
PAEES
46
EHKNN
51
NYEPN
56
LFKTP
61
QRKPS
66
YNQLA
71
STPII
76
FKEQG
81
LTLPL
86
YQSPV
91
KELDK
96
FKLDL
101
GRNVP
106
NSRHK
111
SLRTV
116
KTKMD
121
QADDV
126
SCPLL
131
NSCLS
136
ESPVV
141
LQCTH
146
VTPQR
151
DKSVV
156
CGSLF
161
HTPKF
166
VKGRQ
171
TPKHI
176
SESLG
181
AEVDP
186
DMSWS
191
SSLAT
196
PPTLS
201
STVLI
206
VRNEE
211
ASETV
216
FPHDT
221
TANVK
226
SYFSN
231
HDESL
236
KKNDR
241
FIASV
246
TDSEN
251
TNQRE
256
AASHG
261
FGKTS
266
GNSFK
271
VNSCK
276
DHIGK
281
SMPNV
286
LEDEV
291
YETVV
296
DTSEE
301
DSFSL
306
CFSKC
311
RTKNL
316
QKVRT
321
SKTRK
326
KIFHE
331
ANADE
336
CEKSK
341
NQVKE
346
KYSFV
351
SEVEP
356
NDTDP
361
LDSNV
366
ANQKP
371
FESGS
376
DKISK
381
EVVPS
386
LACEW
391
SQLTL
396
SGLNG
401
AQMEK
406
IPLLH
411
ISSCD
416
QNISE
421
KDLLD
426
TENKR
431
KKDFL
436
TSENS
441
LPRIS
446
SLPKS
451
EKPLN
456
EETVV
461
NKRDE
466
EQHLE
471
SHTDC
476
ILAVK
481
QAISG
486
TSPVA
491
SSFQG
496
IKKSI
501
FRIRE
506
SPKET
511
FNASF
516
SGHMT
521
DPNFK
526
KETEA
531
SESGL
536
EIHTV
541
CSQKE
546
DSLCP
551
NLIDN
556
GSWPA
561
TTTQN
566
SVALK
571
NAGLI
576
STLKK
581
KTNKF
586
IYAIH
591
DETSY
596
KGKKI
601
PKDQK
606
SELIN
611
CSAQF
616
EANAF
621
EAPLT
626
FANAD
631
SGLLH
636
SSVKR
641
SCSQN
646
DSEEP
651
TLSLT
656
SSFGT
661
ILRKC
666
SRNET
671
CSNNT
676
VISQD
681
LDYKE
686
AKCNK
691
EKLQL
696
FITPE
701
ADSLS
706
CLQEG
711
QCEND
716
PKSKK
721
VSDIK
726
EEVLA
731
AACHP
736
VQHSK
741
VEYSD
746
TDFQS
751
QKSLL
756
YDHEN
761
ASTLI
766
LTPTS
771
KDVLS
776
NLVMI
781
SRGKE
786
SYKMS
791
DKLKG
796
NNYES
801
DVELT
806
KNIPM
811
EKNQD
816
VCALN
821
ENYKN
826
VELLP
831
PEKYM
836
RVASP
841
SRKVQ
846
FNQNT
851
NLRVI
856
QKNQE
861
ETTSI
866
SKITV
871
NPDSE
876
ELFSD
881
NENNF
886
VFQVA
891
NERNN
896
LALGN
901
TKELH
906
ETDLT
911
CVNEP
916
IFKNS
921
TMVLY
926
GDTGD
931
KQATQ
936
VSIKK
941
DLVYV
946
LAEEN
951
KNSVK
956
QHIKM
961
TLGQD
966
LKSDI
971
SLNID
976
KIPEK
981
NNDYM
986
NKWAG
991
LLGPI
996
SNHSF
1001
GGSFR
1006
TASNK
1011
EIKLS
1016
EHNIK
1021
KSKMF
1026
FKDIE
1031
EQYPT
1036
SLACV
1041
EIVNT
1046
LALDN
1051
QKKLS
1056
KPQSI
1061
NTVSA
1066
HLQSS
1071
VVVSD
1076
CKNSH
1081
ITPQM
1086
LFSKQ
1091
DFNSN
1096
HNLTP
1101
SQKAE
1106
ITELS
1111
TILEE
1116
SGSQF
1121
EFTQF
1126
RKPSY
1131
ILQKS
1136
TFEVP
1141
ENQMT
1146
ILKTT
1151
SEECR
1156
DADLH
1161
VIMNA
1166
PSIGQ
1171
VDSSK
1176
QFEGT
1181
VEIKR
1186
KFAGL
1191
LKNDC
1196
NKSAS
1201
GYLTD
1206
ENEVG
1211
FRGFY
1216
SAHGT
1221
KLNVS
1226
TEALQ
1231
KAVKL
1236
FSDIE
1241
NISEE
1246
TSAEV
1251
HPISL
1256
SSSKC
1261
HDSVV
1266
SMFKI
1271
ENHND
1276
KTVSE
1281
KNNKC
1286
QLILQ
1291
NNIEM
1296
TTGTF
1301
VEEIT
1306
ENYKR
1311
NTENE
1316
DNKYT
1321
AASRN
1326
SHNLE
1331
FDGSD
1336
SSKND
1341
TVCIH
1346
KDETD
1351
LLFTD
1356
QHNIC
1361
LKLSG
1366
QFMKE
1371
GNTQI
1376
KEDLS
1381
DLTFL
1386
EVAKA
1391
QEACH
1396
GNTSN
1401
KEQLT
1406
ATKTE
1411
QNIKD
1416
FETSD
1421
TFFQT
1426
ASGKN
1431
ISVAK
1436
ESFNK
1441
IVNFF
1446
DQKPE
1451
ELHNF
1456
SLNSE
1461
LHSDI
1466
RKNKM
1471
DILSY
1476
EETDI
1481
VKHKI
1486
LKESV
1491
PVGTG
1496
NQLVT
1501
FQGQP
1506
ERDEK
1511
IKEPT
1516
LLGFH
1521
TASGK
1526
KVKIA
1531
KESLD
1536
KVKNL
1541
FDEKE
1546
QGTSE
1551
ITSFS
1556
HQWAK
1561
TLKYR
1566
EACKD
1571
LELAC
1576
ETIEI
1581
TAAPK
1586
CKEMQ
1591
NSLNN
1596
DKNLV
1601
SIETV
1606
VPPKL
1611
LSDNL
1616
CRQTE
1621
NLKTS
1626
KSIFL
1631
KVKVH
1636
ENVEK
1641
ETAKS
1646
PATCY
1651
TNQSP
1656
YSVIE
1661
NSALA
1666
FYTSC
1671
SRKTS
1676
VSQTS
1681
LLEAK
1686
KWLRE
1691
GIFDG
1696
QPERI
1701
NTADY
1706
VGNYL
1711
YENNS
1716
NSTIA
1721
ENDKN
1726
HLSEK
1731
QDTYL
1736
SNSSM
1741
SNSYS
1746
YHSDE
1751
VYNDS
1756
GYLSK
1761
NKLDS
1766
GIEPV
1771
LKNVE
1776
DQKNT
1781
SFSKV
1786
ISNVK
1791
DANAY
1796
PQTVN
1801
EDICV
1806
EELVT
1811
SSSPC
1816
KNKNA
1821
AIKLS
1826
ISNSN
1831
NFEVG
1836
PPAFR
1841
IASGK
1846
IVCVS
1851
HETIK
1856
KVKDI
1861
FTDSF
1866
SKVIK
1871
ENNEN
1876
KSKIC
1881
QTKIM
1886
AGCYE
1891
ALDDS
1896
EDILH
1901
NSLDN
1906
DECST
1911
HSHKV
1916
FADIQ
1921
SEEIL
1926
QHNQN
1931
MSGLE
1936
KVSKI
1941
SPCDV
1946
SLETS
1951
DICKC
1956
SIGKL
1961
HKSVS
1966
SANTC
1971
GIFST
1976
ASGKS
1981
VQVSD
1986
ASLQN
1991
ARQVF
1996
SEIED
2001
STKQV
2006
FSKVL
2011
FKSNE
2016
HSDQL
2021
TREEN
2026
TAIRT
2031
PEHLI
2036
SQKGF
2041
SYNVV
2046
NSSAF
2051
SGFST
2056
ASGKQ
2061
VSILE
2066
SSLHK
2071
VKGVL
2076
EEFDL
2081
IRTEH
2086
SLHYS
2091
PTSRQ
2096
NVSKI
2101
LPRVD
2106
KRNPE
2111
HCVNS
2116
EMEKT
2121
CSKEF
2126
KLSNN
2131
LNVEG
2136
GSSEN
2141
NHSIK
2146
VSPYL
2151
SQFQQ
2156
DKQQL
2161
VLGTK
2166
VSLVE
2171
NIHVL
2176
GKEQA
2181
SPKNV
2186
KMEIG
2191
KTETF
2196
SDVPV
2201
KTNIE
2206
VCSTY
2211
SKDSE
2216
NYFET
2221
EAVEI
2226
AKAFM
2231
EDDEL
2236
TDSKL
2241
PSHAT
2246
HSLFT
2251
CPENE
2256
EMVLS
2261
NSRIG
2266
KRRGE
2271
PLILV
2276
GEPSI
2281
KRNLL
2286
NEFDR
2291
IIENQ
2296
EKSLK
2301
ASKST
2306
PDGTI
2311
KDRRL
2316
FMHHV
2321
SLEPI
2326
TCVPF
2331
RTTKE
2336
RQEIQ
2341
NPNFT
2346
APGQE
2351
FLSKS
2356
HLYEH
2361
LTLEK
2366
SSSNL
2371
AVSGH
2376
PFYQV
2381
SATRN
2386
EKMRH
2391
LITTG
2396
RPTKV
2401
FVPPF
2406
KTKSH
2411
FHRVE
2416
QCVRN
2421
INLEE
2426
NRQKQ
2431
NIDGH
2436
GSDDS
2441
KNKIN
2446
DNEIH
2451
QFNKN
2456
NSNQA
2461
VAVTF
2466
TKCEE
2471
EPLDL
2476
ITSLQ
2481
NARDI
2486
QDMRI
2491
KKKQR
2496
QRVFP
2501
QPGSL
2506
YLAKT
2511
STLPR
2516
ISLKA
2521
AVGGQ
2526
VPSAC
2531
SHKQL
2536
YTYGV
2541
SKHCI
2546
KINSK
2551
NAESF
2556
QFHTE
2561
DYFGK
2566
ESLWT
2571
GKGIQ
2576
LADGG
2581
WLIPS
2586
NDGKA
2591
GKEEF
2596
YRALC
2601
DTPGV
2606
DPKLI
2611
SRIWV
2616
YNHYR
2621
WIIWK
2626
LAAME
2631
CAFPK
2636
EFANR
2641
CLSPE
2646
RVLLQ
2651
LKYRY
2656
DTEID
2661
RSRRS
2666
AIKKI
2671
MERDD
2676
TAAKT
2681
LVLCV
2686
SDIIS
2691
LSANI
2696
SETSS
2701
NKTSS
2706
ADTQK
2711
VAIIE
2716
LTDGW
2721
YAVKA
2726
QLDPP
2731
LLAVL
2736
KNGRL
2741
TVGQK
2746
IILHG
2751
AELVG
2756
SPDAC
2761
TPLEA
2766
PESLM
2771
LKISA
2776
NSTRP
2781
ARWYT
2786
KLGFF
2791
PDPRP
2796
FPLPL
2801
SSLFS
2806
DGGNV
2811
GCVDV
2816
IIQRA
2821
YPIQW
2826
MEKTS
2831
SGLYI
2836
FRNER
2841
EEEKE
2846
AAKYV
2851
EAQQK
2856
RLEAL
2861
FTKIQ
2866
EEFEE
2871
HEENT
2876
TKPYL
2881
PSRAL
2886
TRQQV
2891
RALQD
2896
GAELY
2901
EAVKN
2906
AADPA
2911
YLEGY
2916
FSEEQ
2921
LRALN
2926
NHRQM
2931
LNDKK
2936
QAQIQ
2941
LEIRK
2946
AMESA
2951
EQKEQ
2956
GLSRD
2961
VTTVW
2966
KLRIV
2971
SYSKK
2976
EKDSV
2981
ILSIW
2986
RPSSD
2991
LYSLL
2996
TEGKR
3001
YRIYH
3006
LATSK
3011
SKSKS
3016
ERANI
3021
QLAAT
3026
KKTQY
3031
QQLPV
3036
SDEIL
3041
FQIYQ
3046
PREPL
3051
HFSKF
3056
LDPDF
3061
QPSCS
3066
EVDLI
3071
GFVVS
3076
VVKKT
3081
GLAPF
3086
VYLSD
3091
ECYNL
3096
LAIKF
3101
WIDLN
3106
EDIIK
3111
PHMLI
3116
AASNL
3121
QWRPE
3126
SKSGL
3131
LTLFA
3136
GDFSV
3141
FSASP
3146
KEGHF
3151
QETFN
3156
KMKNT
3161
VENID
3166
ILCNE
3171
AENKL
3176
MHILH
3181
ANDPK
3186
WSTPT
3191
KDCTS
3196
GPYTA
3201
QIIPG
3206
TGNKL
3211
LMSSP
3216
NCEIY
3221
YQSPL
3226
SLCMA
3231
KRKSV
3236
STPVS
3241
AQMTS
3246
KSCKG
3251
EKEID
3256
DQKNC
3261
KKRRA
3266
LDFLS
3271
RLPLP
3276
PPVSP
3281
ICTFV
3286
SPAAQ
3291
KAFQP
3296
PRSCG
3301
TKYET
3306
PIKKK
3311
ELNSP
3316
QMTPF
3321
KKFNE
3326
ISLLE
3331
SNSIA
3336
DEELA
3341
LINTQ
3346
ALLSG
3351
STGEK
3356
QFISV
3361
SESTR
3366
TAPTS
3371
SEDYL
3376
RLKRR
3381
CTTSL
3386
IKEQE
3391
SSQAS
3396
TEECE
3401
KNKQD
3406
TITTK
3411
KYI
3416
Mutation Information
DNA mutation:
None
Peptide Range:
1733 ~ 1757
Mut AA position:
1745 (13 in Wild Type peptide)
Alignment
Wild Type:
"SEKQDTYLSNSSMSNSYSYHSDEVY
||||||||||||.||||||||||||
Mutant:
SEKQDTYLSNSSVSNSYSYHSDEVY"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) BRCA2
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay