Immunogenicity 8608
Sample ID
3995
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
TOPAZ1
Transcript ID
NM_001145030
HLA INFO
A*30:02
TCR INFO
No TCR info found!
Full length protein sequence (1692 aa)
MRRPP
1
PLGPT
6
TASGP
11
EGNVR
16
NLQKR
21
QAPGP
26
GAAGG
31
CGPEA
36
GGCRE
41
NKQKR
46
RMVAR
51
ATPGR
56
GEVES
61
DKSVA
66
ASGAG
71
KAARR
76
QVEGR
81
RGPVS
86
PSDSS
91
DPRGL
96
EAAKE
101
AELPL
106
QTERH
111
TKEKR
116
KVTEA
121
SSDDP
126
QPGLD
131
LVRKE
136
SLTSS
141
ESFQT
146
VECLQ
151
SLGKE
156
SIIEG
161
IKRRI
166
RNKKL
171
KSLEN
176
PPLKI
181
TENEA
186
TQNIK
191
VEFQD
196
ELYKN
201
TPKYS
206
CNILS
211
PEVEN
216
NSVLK
221
LRDCN
226
CFPHS
231
KGCND
236
ENNLP
241
YKPDG
246
GCMHV
251
AENFS
256
KKENL
261
RSLAE
266
KSDTN
271
SIPQL
276
LQTEE
281
NVMGV
286
NKLLP
291
EESDL
296
YQSKT
301
NGLLS
306
CLQHE
311
KNKYS
316
IEESS
321
VGRKP
326
RKRMK
331
LSEKA
336
DETVT
341
EMNFS
346
NEYNK
351
SELML
356
QENQM
361
IADGK
366
EAETK
371
SPLNV
376
LRKVS
381
HNTVS
386
LMDHL
391
LSVPE
396
TVEKE
401
TSSEH
406
HVNAV
411
FQKTI
416
EPLLK
421
EETEN
426
ASEPL
431
GYESM
436
ASKED
441
FKSMK
446
SFIGK
451
SPNEY
456
HIERR
461
SSRED
466
LRSAS
471
EELKL
476
SCQRT
481
IPMTG
486
KRTWP
491
YYSCA
496
RISAW
501
CWKKA
506
SLPES
511
SYFLR
516
GSQES
521
CRQVD
526
VPKHQ
531
TNQTH
536
LTDSK
541
LLLQS
546
SLTET
551
NTESS
556
SKEKL
561
DSNSN
566
CLSSV
571
SAVEP
576
TLMVI
581
KEPII
586
KDDKK
591
IKSEE
596
LSRRG
601
SEVIS
606
NTTED
611
TQLTS
616
ETQSL
621
TGNKK
626
KARGN
631
LTKLN
636
LTATS
641
KDGQE
646
ANNSA
651
GKTIH
656
RKACI
661
AQQTF
666
IVPDL
671
VKILN
676
TGRLT
681
NFKIP
686
LLKNK
691
SEKRK
696
EVNAK
701
SSERE
706
AYSPL
711
ELLDN
716
LSGAD
721
VRQNR
726
SKENV
731
SMMML
736
GPQTL
741
SIRNS
746
VTPVQ
751
ASSDS
756
FYNKK
761
SYSIS
766
PSFTK
771
QGNNS
776
KPSNH
781
VSEPG
786
NIVSN
791
KEVAS
796
LTVEN
801
NAFSC
806
DPGYV
811
EKSPS
816
FCCNE
821
QETFR
826
PVSSE
831
VRGRK
836
ITKNF
841
SEVGF
846
PDILK
851
AYEDD
856
VLLID
861
VIQDD
866
PDLFG
871
VSNEG
876
ELSFT
881
SEVPK
886
ISQEP
891
NVAGE
896
HQSTD
901
SKYME
906
TPVKK
911
EPSDD
916
LRELP
921
VLDCG
926
WIKPD
931
ICASN
936
SAESE
941
IKRDP
946
KDVNT
951
SLGEV
956
ANETS
961
ENETL
966
GDFSE
971
QIKGS
976
DLDEK
981
HRFTD
986
KVITK
991
EEKEN
996
IYEVC
1001
KSKDS
1006
RNADF
1011
MVGEC
1016
QFAVP
1021
VPKPL
1026
CLLVP
1031
PLNLS
1036
GRQED
1041
TILNT
1046
WMNDF
1051
RFLGK
1056
HSVLK
1061
LQNPE
1066
TCEIF
1071
KREKN
1076
VGVFQ
1081
KSLGL
1086
MIPYK
1091
YCKFH
1096
FNTLR
1101
GCERP
1106
LCKFA
1111
HVPEQ
1116
GDEKV
1121
CMDVF
1126
KKYIN
1131
INELC
1136
LLQRA
1141
VNIFM
1146
EYYRK
1151
FPPGV
1156
YFDLQ
1161
VLNDL
1166
LNSLL
1171
KHCLL
1176
KEVFQ
1181
IVNLS
1186
IMVKM
1191
LPSLK
1196
ILLNI
1201
FEYVA
1206
TMKLR
1211
NAVPA
1216
LIDIF
1221
CKLVE
1226
AGMVL
1231
DPEHF
1236
NYIVK
1241
LLYQV
1246
QASKQ
1251
EITAV
1256
LEMKS
1261
RLQMR
1266
RFKKN
1271
WKCDL
1276
DSALN
1281
KLEHC
1286
KEKGD
1291
WTKLG
1296
KLYIN
1301
VKMGC
1306
EKFAD
1311
FQTFC
1316
ACIAE
1321
TLTKN
1326
YEDER
1331
PDIPF
1336
CEFAE
1341
TVSKD
1346
PQNSK
1351
VDKGV
1356
LGRIG
1361
ISAMY
1366
FYHKL
1371
LQWSK
1376
GRKVL
1381
EKLYE
1386
LKIHF
1391
TSLKG
1396
LIGPE
1401
KLASR
1406
CQIVN
1411
VAAEI
1416
FLKSG
1421
SLDGA
1426
IWVMR
1431
ESEWI
1436
INTPL
1441
WPCDR
1446
LDVLN
1451
RHNLL
1456
CTIAH
1461
EILAK
1466
SLYRQ
1471
TFEVL
1476
QNLPG
1481
FQNSQ
1486
ETVEV
1491
SQYSL
1496
LFNKL
1501
LGSCI
1506
ESSSL
1511
GMSSS
1516
VAEFM
1521
ISKSI
1526
PIDFS
1531
FLRRL
1536
ITSLG
1541
RSRLW
1546
LKARA
1551
HYKSA
1556
LSLGC
1561
YPPLE
1566
GNLYR
1571
KLLLI
1576
PSYLS
1581
EIEML
1586
LAIEI
1591
FMVSN
1596
ASSIQ
1601
SPGTS
1606
TQILQ
1611
IVLKR
1616
CEDNQ
1621
SRSND
1626
DYQAA
1631
VERLI
1636
MAARI
1641
SDPKL
1646
FVKHM
1651
TVNVN
1656
KEQVY
1661
SLEHC
1666
SALKW
1671
LKENM
1676
KWAGK
1681
VWLFS
1686
NH
1691
Mutation Information
DNA mutation:
None
Peptide Range:
32 ~ 56
Mut AA position:
44 (13 in Wild Type peptide)
Alignment
Wild Type:
"AAGGCGPEAGGCRENKQKRRMVARA
||||||||||||.||||||||||||
Mutant:
AAGGCGPEAGGCWENKQKRRMVARA"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) TOPAZ1
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay