Immunogenicity 8742

summary
Sample ID
4007
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
UBE3C
Transcript ID
NM_014671
HLA INFO
DQA*01:02 / DQB*06:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*01:02 DQB*06:02
sequence
Full length protein sequence (1083 aa)
MFSFE
1
GDFKT
6
RPKVS
11
LGGAS
16
RKEEK
21
ASLLH
26
RTQEE
31
RRKRE
36
EERRR
41
LKNAI
46
IIQSF
51
IRGYR
56
DRKQQ
61
YSIQR
66
SAFDR
71
CATLS
76
QSGGA
81
FPIAN
86
GPNLT
91
LLVRQ
96
LLFFY
101
KQNED
106
SKRLI
111
WLYQN
116
LIKHS
121
SLFVK
126
QLDGS
131
ERLTC
136
LFQIK
141
RLMSL
146
CCRLL
151
QNCND
156
DSLNV
161
ALPMR
166
MLEVF
171
SSENT
176
YLPVL
181
QDASY
186
VVSVI
191
EQILH
196
YMIHN
201
GYYRS
206
LYLLI
211
NSKLP
216
SSIEY
221
SDLSR
226
VPIAK
231
ILLEN
236
VLKPL
241
HFTYN
246
SCPEG
251
ARQQV
256
FTAFT
261
EEFLA
266
APFTD
271
QIFHF
276
IIPAL
281
ADAQT
286
VFPYE
291
PFLNA
296
LLLIE
301
SRCSR
306
KSGGA
311
PWLFY
316
FVLTV
321
GENYL
326
GALSE
331
EGLLV
336
YLRVL
341
QTFLS
346
QLPVS
351
PASAS
356
CHDSA
361
SDSEE
366
ESEEA
371
DKPSS
376
PEDGR
381
LSVSY
386
ITEEC
391
LKKLD
396
TKQQT
401
NTLLN
406
LVWRD
411
SASEE
416
VFTTM
421
ASVCH
426
TLMVQ
431
HRMMV
436
PKVRL
441
LYSLA
446
FNARF
451
LRHLW
456
FLISS
461
MSTRM
466
ITGSM
471
VPLLQ
476
VISRG
481
SPMSF
486
EDSSR
491
IIPLF
496
YLFSS
501
LFSHS
506
LISIH
511
DNEFF
516
GDPIE
521
VVGQR
526
QSSMM
531
PFTLE
536
ELIML
541
SRCLR
546
DACLG
551
IIKLA
556
YPETK
561
PEVRE
566
EYITA
571
FQSIG
576
VTTSS
581
EMQQC
586
IQMEQ
591
KRWIQ
596
LFKVI
601
TNLVK
606
MLKSR
611
DTRRN
616
FCPPN
621
HWLSE
626
QEDIK
631
ADKVT
636
QLYVP
641
ASRHV
646
WRFRR
651
MGRIG
656
PLQST
661
LDVGL
666
ESPPL
671
SVSEE
676
RQLAV
681
LTELP
686
FVVPF
691
EERVK
696
IFQRL
701
IYADK
706
QEVQG
711
DGPFL
716
DGINV
721
TIRRN
726
YIYED
731
AYDKL
736
SPENE
741
PDLKK
746
RIRVH
751
LLNAH
756
GLDEA
761
GIDGG
766
GIFRE
771
FLNEL
776
LKSGF
781
NPNQG
786
FFKTT
791
NEGLL
796
YPNPA
801
AQMLV
806
GDSFA
811
RHYYF
816
LGRML
821
GKALY
826
ENMLV
831
ELPFA
836
GFFLS
841
KLLGT
846
SADVD
851
IHHLA
856
SLDPE
861
VYKNL
866
LFLKS
871
YEDDV
876
EELGL
881
NFTVV
886
NNDLG
891
EAQVV
896
ELKFG
901
GKDIP
906
VTSAN
911
RIAYI
916
HLVAD
921
YRLNR
926
QIRQH
931
CLAFR
936
QGLAN
941
VVSLE
946
WLRMF
951
DQQEI
956
QVLIS
961
GAQVP
966
ISLED
971
LKSFT
976
NYSGG
981
YSADH
986
PVIKV
991
FWRVV
996
EGFTD
1001
EEKRK
1006
LLKFV
1011
TSCSR
1016
PPLLG
1021
FKELY
1026
PAFCI
1031
HNGGS
1036
DLERL
1041
PTAST
1046
CMNLL
1051
KLPEF
1056
YDETL
1061
LRSKL
1066
LYAIE
1071
CAAGF
1076
ELS
1081
Mutation Information
DNA mutation:
None
Peptide Range:
660 ~ 684
Mut AA position:
672 (13 in Wild Type peptide)
Alignment
Wild Type:
"GPLQSTLDVGLESPPLSVSEERQLA
||||||||||||.||||||||||||
Mutant:
GPLQSTLDVGLEPPPLSVSEERQLA"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) UBE3C

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay