Immunogenicity 8754

summary
Sample ID
3995
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
SOS1
Transcript ID
NM_005633
HLA INFO
DQA*05:01 / DQB*02:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*05:01 DQB*02:02
sequence
Full length protein sequence (1333 aa)
MQAQQ
1
LPYEF
6
FSEEN
11
APKWR
16
GLLVP
21
ALKKV
26
QGQVH
31
PTLES
36
NDDAL
41
QYVEE
46
LILQL
51
LNMLC
56
QAQPR
61
SASDV
66
EERVQ
71
KSFPH
76
PIDKW
81
AIADA
86
QSAIE
91
KRKRR
96
NPLSL
101
PVEKI
106
HPLLK
111
EVLGY
116
KIDHQ
121
VSVYI
126
VAVLE
131
YISAD
136
ILKLV
141
GNYVR
146
NIRHY
151
EITKQ
156
DIKVA
161
MCADK
166
VLMDM
171
FHQDV
176
EDINI
181
LSLTD
186
EEPST
191
SGEQT
196
YYDLV
201
KAFMA
206
EIRQY
211
IRELN
216
LIIKV
221
FREPF
226
VSNSK
231
LFSAN
236
DVENI
241
FSRIV
246
DIHEL
251
SVKLL
256
GHIED
261
TVEMT
266
DEGSP
271
HPLVG
276
SCFED
281
LAEEL
286
AFDPY
291
ESYAR
296
DILRP
301
GFHDR
306
FLSQL
311
SKPGA
316
ALYLQ
321
SIGEG
326
FKEAV
331
QYVLP
336
RLLLA
341
PVYHC
346
LHYFE
351
LLKQL
356
EEKSE
361
DQEDK
366
ECLKQ
371
AITAL
376
LNVQS
381
GMEKI
386
CSKSL
391
AKRRL
396
SESAC
401
RFYSQ
406
QMKGK
411
QLAIK
416
KMNEI
421
QKNID
426
GWEGK
431
DIGQC
436
CNEFI
441
MEGTL
446
TRVGA
451
KHERH
456
IFLFD
461
GLMIC
466
CKSNH
471
GQPRL
476
PGASN
481
AEYRL
486
KEKFF
491
MRKVQ
496
INDKD
501
DTNEY
506
KHAFE
511
IILKD
516
ENSVI
521
FSAKS
526
AEEKN
531
NWMAA
536
LISLQ
541
YRSTL
546
ERMLD
551
VTMLQ
556
EEKEE
561
QMRLP
566
SADVY
571
RFAEP
576
DSEEN
581
IIFEE
586
NMQPK
591
AGIPI
596
IKAGT
601
VIKLI
606
ERLTY
611
HMYAD
616
PNFVR
621
TFLTT
626
YRSFC
631
KPQEL
636
LSLII
641
ERFEI
646
PEPEP
651
TEADR
656
IAIEN
661
GDQPL
666
SAELK
671
RFRKE
676
YIQPV
681
QLRVL
686
NVCRH
691
WVEHH
696
FYDFE
701
RDAYL
706
LQRME
711
EFIGT
716
VRGKA
721
MKKWV
726
ESITK
731
IIQRK
736
KIARD
741
NGPGH
746
NITFQ
751
SSPPT
756
VEWHI
761
SRPGH
766
IETFD
771
LLTLH
776
PIEIA
781
RQLTL
786
LESDL
791
YRAVQ
796
PSELV
801
GSVWT
806
KEDKE
811
INSPN
816
LLKMI
821
RHTTN
826
LTLWF
831
EKCIV
836
ETENL
841
EERVA
846
VVSRI
851
IEILQ
856
VFQEL
861
NNFNG
866
VLEVV
871
SAMNS
876
SPVYR
881
LDHTF
886
EQIPS
891
RQKKI
896
LEEAH
901
ELSED
906
HYKKY
911
LAKLR
916
SINPP
921
CVPFF
926
GIYLT
931
NILKT
936
EEGNP
941
EVLKR
946
HGKEL
951
INFSK
956
RRKVA
961
EITGE
966
IQQYQ
971
NQPYC
976
LRVES
981
DIKRF
986
FENLN
991
PMGNS
996
MEKEF
1001
TDYLF
1006
NKSLE
1011
IEPRN
1016
PKPLP
1021
RFPKK
1026
YSYPL
1031
KSPGV
1036
RPSNP
1041
RPGTM
1046
RHPTP
1051
LQQEP
1056
RKISY
1061
SRIPE
1066
SETES
1071
TASAP
1076
NSPRT
1081
PLTPP
1086
PASGA
1091
SSTTD
1096
VCSVF
1101
DSDHS
1106
SPFHS
1111
SNDTV
1116
FIQVT
1121
LPHGP
1126
RSASV
1131
SSISL
1136
TKGTD
1141
EVPVP
1146
PPVPP
1151
RRRPE
1156
SAPAE
1161
SSPSK
1166
IMSKH
1171
LDSPP
1176
AIPPR
1181
QPTSK
1186
AYSPR
1191
YSISD
1196
RTSIS
1201
DPPES
1206
PPLLP
1211
PREPV
1216
RTPDV
1221
FSSSP
1226
LHLQP
1231
PPLGK
1236
KSDHG
1241
NAFFP
1246
NSPSP
1251
FTPPP
1256
PQTPS
1261
PHGTR
1266
RHLPS
1271
PPLTQ
1276
EVDLH
1281
SIAGP
1286
PVPPR
1291
QSTSQ
1296
HIPKL
1301
PPKTY
1306
KREHT
1311
HPSMH
1316
RDGPP
1321
LLENA
1326
HSS
1331
Mutation Information
DNA mutation:
None
Peptide Range:
297 ~ 321
Mut AA position:
309 (13 in Wild Type peptide)
Alignment
Wild Type:
"SYARDILRPGFHDRFLSQLSKPGAA
||||||||||||.||||||||||||
Mutant:
SYARDILRPGFHYRFLSQLSKPGAA"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) SOS1

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay