Immunogenicity 880

summary
Sample ID
3942
Response
Negative
Tumor Type
Rectal cancer
Gene Symbol
POLR2M
Transcript ID
ENST00000587652
HLA INFO
DQA*02:01 / DQB*02:02
TCR INFO

No TCR info found!

T cell Tumor cell { DQA*02:01 DQB*02:02
sequence
Full length protein sequence (765 aa)
MLRST
1
STVTL
6
LSGGA
11
ARTPG
16
APSRR
21
ANVCR
26
LRLTV
31
PPESP
36
VPEQC
41
EKKIE
46
RKEQL
51
LDLSN
56
GEPTR
61
KLPQG
66
VVYGV
71
VRRSD
76
QNQQK
81
EMVVY
86
GWSTS
91
QLKEE
96
MNYIK
101
DVRAT
106
LEKVR
111
KRMYG
116
DYDEM
121
RQKIR
126
QLTQE
131
LSVSH
136
AQQEY
141
LENHI
146
QTQSS
151
ALDRF
156
NAMNS
161
ALASD
166
SIGLQ
171
KTLVD
176
VTLEN
181
SNIKD
186
QIRNL
191
QQTYE
196
ASMDK
201
LREKQ
206
RQLEV
211
AQVEN
216
QLLKM
221
KVESS
226
QEANA
231
EVMRE
236
MTKKL
241
YSQYE
246
EKLQE
251
EQRKH
256
SAEKE
261
ALLEE
266
TNSFL
271
KAIEE
276
ANKKM
281
QAAEI
286
SLEEK
291
DQRIG
296
ELDRL
301
IERME
306
KERHQ
311
LQLQL
316
LEHET
321
EMSGE
326
LTDSD
331
KERYQ
336
QLEEA
341
SASLR
346
ERIRH
351
LDDMV
356
HCQQK
361
KVKQM
366
VEEIE
371
SLKKK
376
LQQKQ
381
LLILQ
386
LLEKI
391
SFLEG
396
ENNEL
401
QSRLD
406
YLTET
411
QAKTE
416
VETRE
421
IGVGC
426
DLLPR
431
KFICK
436
LPDKG
441
KKIFD
446
SFAKL
451
KAAIA
456
ECEEV
461
RRKSE
466
LFNPV
471
SLDCK
476
LRQKA
481
IAEVD
486
VGTDK
491
AQNSD
496
PILDT
501
SSLVP
506
GCSSV
511
DNIKS
516
SQTSQ
521
NQGLG
526
RPTLE
531
GDEET
536
SEVEY
541
TVNKG
546
PASSN
551
RDRVP
556
PSSEA
561
SEHHP
566
RHRVS
571
SQAED
576
TSSSF
581
DNLFI
586
DRLQR
591
ITIAD
596
QGEQQ
601
SEENA
606
STKNL
611
TGLSS
616
GTEKK
621
PHYME
626
VLEMR
631
AKNPV
636
PQLRK
641
FKTNV
646
LPFRQ
651
NDSSS
656
HCQKS
661
GSPIS
666
SEERR
671
RRDKQ
676
HLDDI
681
TAARL
686
LPLHH
691
MPTQL
696
LSIEE
701
SLALQ
706
KQQKQ
711
NYEEM
716
QAKLA
721
AQKLA
726
ERLNI
731
KMRSY
736
NPEGE
741
SSGRY
746
REVRD
751
EDDDW
756
SSDEF
761
Mutation Information
DNA mutation:
None
Peptide Range:
511 ~ 535
Mut AA position:
523 (13 in Wild Type peptide)
Alignment
Wild Type:
"GCSSVDNIKSSQTSQNQGLGRPTLE
||||||||||||.||||||||||||
Mutant:
GCSSVDNIKSSQPSQNQGLGRPTLE"
reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) POLR2M

clinic trial
Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment
minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay