Immunogenicity 941
Sample ID
3971
Response
Negative
Tumor Type
Colon cancer
Gene Symbol
TOP1MT
Transcript ID
ENST00000329245
HLA INFO
C*01:02
TCR INFO
No TCR info found!
Full length protein sequence (601 aa)
MRVVR
1
LLRLR
6
AALTL
11
LGEVP
16
RRPAS
21
RGVPG
26
SRRTQ
31
KGSGA
36
RWEKE
41
KHEDG
46
VKWRQ
51
LEHKG
56
PYFAP
61
PYEPL
66
PDGVR
71
FFYEG
76
RPVRL
81
SVAAE
86
EVATF
91
YGRML
96
DHEYT
101
TKEVF
106
RKNFF
111
NDWRK
116
EMAVE
121
EREVI
126
KSLDK
131
CDFTE
136
IHRYF
141
VDKAA
146
ARKVL
151
SREEK
156
QKLKE
161
EAEKL
166
QQEFG
171
YCILD
176
GHQEK
181
IGNFK
186
IEPPG
191
LFRGR
196
GDHPK
201
MGMLK
206
RRITP
211
EDVVI
216
NCSRD
221
SKIPE
226
PPAGH
231
QWKEV
236
RSDNT
241
VTWLA
246
AWTES
251
VQNSI
256
KYIML
261
NPCSK
266
LKGET
271
AWQKF
276
ETARR
281
LRGFV
286
DEIRS
291
QYRAD
296
WKSRE
301
MKTRQ
306
RAVAL
311
YFIDK
316
LALRA
321
GNEKE
326
DGEAA
331
DTVGC
336
CSLRV
341
EHVQL
346
HPEAD
351
GCQHV
356
VEFDF
361
LGKDC
366
IRYYN
371
RVPVE
376
KPVYK
381
NLQLF
386
MENKD
391
PRDDL
396
FDRLT
401
TTSLN
406
KHLQE
411
LMDGL
416
TAKVF
421
RTYNA
426
SITLQ
431
EQLRA
436
LTRAE
441
DSIAA
446
KILSY
451
NRANR
456
VVAIL
461
CNHQR
466
ATPST
471
FEKSM
476
QNLQT
481
KIQAK
486
KEQVA
491
EARAE
496
LRRAR
501
AEHKA
506
QGDGK
511
SRSVL
516
EKKRR
521
LLEKL
526
QEQLA
531
QLSVQ
536
ATDKE
541
ENKQV
546
ALGTS
551
KLNYL
556
DPRIS
561
IAWCK
566
RFRVP
571
VEKIY
576
SKTQR
581
ERFAW
586
ALAMA
591
GEDFE
596
F
601
Mutation Information
DNA mutation:
None
Peptide Range:
188 ~ 212
Mut AA position:
200 (13 in Wild Type peptide)
Alignment
Wild Type:
"NFKIEPPGLFRGRGDHPKMGMLKRR
||||||||||||.||||||||||||
Mutant:
NFKIEPPGLFRGSGDHPKMGMLKRR"
Science, 2015
Immunogenicity of somatic mutations in human gastrointestinal cancersGene Name (from Reference) TOP1MT
Checkpoint
Blockade
None
ACT
None
Vaccination
None
Curative
Effect
None
minimal_peptide
None
Antigen
Type
TMG RNA
T-cell
Source
TILs
APC
Type
autologous DCs
Assay
IFNg ELISPOT assay